Still challenging the pattern separation dogma: 'quiero retruco'.
Still challenging the pattern separation dogma: 'quiero retruco'.
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仍在挑战模式分离教条：“quiero retruco”。
DOI：
10.1016/j.tics.2021.08.007
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发表时间：
2021
影响因子：
19.9
通讯作者：
Quian Quiroga R
中科院分区：
文献类型：
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作者：
Quian Quiroga R
讨论了人类海马神经元分级编码的含义（即，神经元对一个人的反应最好，而对其他相关的神经元的反应较差），考虑到我们已经展示了完全相反的情况，即一种近乎二元的编码，其中神经元主要对相关的人[10]或同一人的不同图片做出相同的反应[11]。 Ekstrom、Suthana、Stark 和 Yassa 支持人类海马模式分离的论点已在 [3] 中被驳斥。更普遍的是，神经科学存在强烈的偏见，表现为一种倾向，即认为在实验室研究的动物中发现的相同原理也应该至少在某种程度上适用于人类。我强烈反对这一观点[12]，因为尽管某些神经元
discusses the implications of a graded coding in human hippocampal neurons (ie, neurons responding best to one person and less so to other associated ones) considering that we have shown exactly the opposite, that is, a nearly binary coding in which neurons mainly respond equally to associated persons [10] or to different pictures of the same person [11]. Arguments in favour of human hippocampal pattern separation by Ekstrom, Suthana, Stark, and Yassa were already refuted in [3].More generally, there is a strong bias in neuroscience that manifests in a tendency to believe that the same principles found in animals studied in the laboratory should also apply, at least to some degree, to humans. I have strongly argued otherwise [12], because, although some neuronal