Maternal Breastfeeding History and Alzheimer's Disease Risk
Maternal Breastfeeding History and Alzheimer's Disease Risk
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DOI：
10.3233/jad-130152
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发表时间：
2013-01-01
影响因子：
4
通讯作者：
Knapp, Leslie A.
中科院分区：
文献类型：
--
作者：
Fox, Molly;Berzuini, Carlo;Knapp, Leslie A.
近年来，早期和中年因素对晚年认知功能的影响引起了科学界和公众的兴趣，特别是在痴呆症的激素危险因素方面。有大量证据表明生殖史影响阿尔茨海默病（AD）的病因。在这里，我们展示了母乳喂养史如何影响女性患AD的风险。研究人员收集了一组英国老年妇女的生殖史数据，并对她们进行了AD诊断访谈。使用Cox比例风险模型，我们发现较长的母乳喂养时间对应于AD风险降低（p < 0.01, n = 81）。母乳喂养的女性患AD的风险低于未母乳喂养的女性（p = 0.017, n = 81）。母乳喂养的做法是一个重要的修改累积内源性激素暴露的母亲。卵巢激素剥夺和/或母乳喂养的胰岛素敏感性益处可能是观察到的AD风险降低的原因。关于激素对AD风险影响的未来研究应考虑生殖史如何导致内源性激素暴露的变化，以及这可能如何影响激素与AD之间的关系。
The effect of early and midlife factors on later-life cognitive function has attracted scientific and public interest in recent years, especially with respect to hormonal risk factors for dementia. There is substantial evidence for reproductive history affecting Alzheimer's disease (AD) etiology. Here, we demonstrate how breastfeeding history affects women's risk of AD. Reproductive history data was collected, and AD diagnostic interviews were performed, for a cohort of elderly British women. Using Cox proportional-hazard models, we find that longer breastfeeding duration corresponded to reduced risk of AD (p < 0.01, n = 81). Women who breastfed had lower AD risk than women who did not breastfeed (p = 0.017, n = 81). Breastfeeding practices are an important modifier of cumulative endogenous hormone exposure for mothers. Ovarian hormone deprivation and/or insulin sensitivity benefits of breastfeeding may be responsible for the observed reduction in AD risk. Future studies concerning hormone effects on AD risk should consider how reproductive history leads to variation in endogenous hormone exposure and how this may influence the relationship between hormones and AD.