Corpus callosum morphology in children with Tourette syndrome and attention deficit hyperactivity disorder
Corpus callosum morphology in children with Tourette syndrome and attention deficit hyperactivity disorder
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DOI：
10.1212/wnl.47.2.477
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发表时间：
1996-08-01
期刊：
影响因子：
9.9
通讯作者：
Reiss, AL
中科院分区：
文献类型：
--
作者：
Baumgardner, TL;Singer, HS;Reiss, AL
本研究的目的是研究图雷特综合征（TS）和注意缺陷多动障碍（ADHD）的胼胝体（CC）形态学，以确定这些疾病是否会影响明显的区域差异。77名儿童和青少年，年龄在6到16岁之间，由四个研究组组成：16名TS患者，21名TS合并ADHD患者，13名ADHD患者和27名未受影响的对照组。采用半自动化的计算机辅助程序测量CC的总面积、五个亚区、中心线长度、周长和弯曲角度。MRI数据使用几种统计方法进行分析，主要是双尾方差分析，以检验TS和ADHD状态的影响，同时控制年龄、性别和总颅内面积（脑大小的估计）的影响。TS与5个分区中的4个分区的面积、总面积和CC周长的显著增加有关，ADHD与吻侧体面积的显著减少有关。TS与ADHD因素之间没有相互作用。这些发现表明，TS患儿CC的面积更大，而且这种差异与年龄、惯用手、颅内面积和ADHD的诊断无关。我们的发现支持了TS和ADHD的神经生物学机制涉及额叶/皮层下回路的假设。
The aim of this study was to investigate the morphology of the corpus callosum (CC) in Tourette syndrome (TS) and attention deficit hyperactivity disorder (ADHD) to determine whether these conditions affect distinct regional differences. Seventy-seven children and adolescents, aged 6 to 16 years, comprised the four research groups-16 patients with TS, 21 patients with TS plus ADHD, 13 patients with ADHD, and 27 unaffected control subjects. A semiautomated, computer-assisted procedure was used to measure the total area, five subregions, centerline length, perimeter, and bending angle of the CC. MRI data were analyzed using several statistical methods, primarily two-tailed analysis of variance to test the effects of TS and ADHD status, while controlling for the influence of age, gender, and total intracranial area (an estimate of brain size). TS was associated with significant increases in the area of four of five subdivisions, the total area, and the perimeter of the CC. ADHD was associated with a significant decrease in the area of the rostral body. There were no interactions between TS and ADHD factors. These findings suggest that the area of the CC is larger in children with TS, and that this difference is independent of age, handedness, intracranial area, and the diagnosis of ADHD. Our findings support hypotheses that the neurobiologic mechanisms in TS and ADHD involve frontal/subcortical circuits.