Unique effect of coordination of an alkene moiety in products on ruthenium-catalyzed chemoselective C-H alkenylation.
Unique effect of coordination of an alkene moiety in products on ruthenium-catalyzed chemoselective C-H alkenylation.
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DOI：
10.1021/ol802819b
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发表时间：
2009-01
期刊：
影响因子：
5.2
通讯作者：
S. Ueno;Takuya Kochi;N. Chatani;F. Kakiuchi
中科院分区：
文献类型：
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作者：
S. Ueno;Takuya Kochi;N. Chatani;F. Kakiuchi
Ru催化的2‘-烷氧基苯乙酮与烯基硼酸酯的烯基化反应提供了邻位C-H烯基化产物，而不牺牲其他邻位上的乙醚官能团。芳氧基Ru络合物具有优异的化学选择性和较高的产品收率。通过将C-H烯基化产物中的烯基部分配位到Ru中心，有效地抑制了C-O键的断裂。
Ruthenium-catalyzed alkenylation of 2'-alkoxyacetophenones with alkenylboronates provides ortho C-H alkenylation products without sacrificing an ether functional group at the other ortho position. Both excellent chemoselectivity and high product yields are achieved with an aryloxo ruthenium complex. The effective suppression of the C-O bond cleavage was attained by coordination of the alkenyl moiety in the C-H alkenylation product to the ruthenium center.