Relationship of day-to-day reproductive hormone levels to sleep in midlife women
Relationship of day-to-day reproductive hormone levels to sleep in midlife women
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DOI：
10.1001/archinte.165.20.2370
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发表时间：
2005-11-14
影响因子：
--
通讯作者：
Powell, LH
中科院分区：
文献类型：
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作者：
Kravitz, HM;Janssen, I;Powell, LH
背景：在全国妇女健康研究的每日激素研究部分，我们分析了630名年龄在43岁至53岁之间的女性的单次月经周期数据，以确定激素水平是否与女性进入更年期过渡时的睡眠问题有关。方法：女性记录她们前一晚是否有睡眠困难。每天采集晨尿标本，测定促黄体生成素、促卵泡激素、雌二醇代谢物（即雌酮偶联物）和孕酮代谢物（孕二醇葡萄糖醛酸盐）的水平。根据出血模式将妇女分为绝经前和早期围绝经期。结果：围绝经期妇女报告睡眠问题的平均调整几率比绝经前妇女高29%。在绝经期的两组女性中，睡眠问题出现在月经周期开始或结束时的比例最高。在控制协变量后，妊娠二醇葡萄糖醛酸水平与围绝经期妇女睡眠困难增加有关，促卵泡激素水平与绝经前妇女睡眠困难增加有关。情绪和血管舒缩症状是导致睡眠困难的最强烈和最一致的共同因素。结论：在这个以社区为基础的中年妇女样本中，在月经周期的开始和结束时观察到睡眠最困难。
Background: We analyzed data from a single menstrual cycle from 630 women, aged 43 to 53 years, in the Daily Hormone Study component of the Study of Women's Health Across the Nation to determine whether hormone levels are associated with trouble sleeping as women enter the menopausal transition. Methods: Women recorded whether they had trouble sleeping the previous night. Morning urine specimens were obtained for daily determinations of levels of luteinizing hormone, follicle-stimulating hormone, estradiol metabolites (ie, estrone conjugates), and the progesterone metabolite (pregnanediol glucuronide). Women were categorized as premenopausal or early perimenopausal by bleeding patterns.Results: Average adjusted odds of reporting trouble sleeping were 29% higher in perimenopausal than in premenopausal women. The highest percentages of women in both menopausal groups reported trouble sleeping in the beginning or at the end of their cycle. After controlling for covariates, pregnanediol glucuronide level was associated with increased trouble sleeping in perimenopausal women and follicle-stimulating hormone level was associated with increased trouble sleeping in premenopausal women. Mood and vasomotor symptoms were the strongest and most consistent cocontributors to trouble sleeping.Conclusion: In this community-based sample of middle-aged women, the most trouble sleeping was observed at the beginning and end of the menstrual cycle.