Effects of selective-wavelength block filters on pupillary light reflex under red and blue light stimuli
Effects of selective-wavelength block filters on pupillary light reflex under red and blue light stimuli
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DOI：
10.1007/s10384-011-0116-1
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发表时间：
2012-03-01
影响因子：
2.4
通讯作者：
Shimizu, Kimiya
中科院分区：
文献类型：
--
作者：
Ishikawa, Hitoshi;Onodera, Asami;Shimizu, Kimiya
为探讨含黑视素的视网膜神经节细胞（mRGCs）在什么波长下脱髓鞘以及它们如何影响光刺激引起的瞳孔收缩，用红外瞳孔仪测定了30名正常人的瞳孔对光反射。选择100 cd/m2的蓝光刺激（470 nm）和红光刺激（635 nm）。使用了可以选择性地去除波长440和470 nm的选择性波长阻挡滤波器。同时进行视觉测试，观察滤光片对视力、色觉和对比敏感度的影响。当受到光刺激时，瞳孔短暂收缩，然后向稳定状态的直径稳定。当佩戴470 nm阻断滤光片时，认为由mRGCs介导的瞳孔收缩的持续阶段不稳定，但在蓝光刺激下对瞳孔收缩的初始阶段没有影响。这些结果表明，人类的mRGC可能对470 nm波长的100 cd/m2光产生反应，并且有可能影响光反射的持续阶段而不改变视觉性能。
To investigate at which wavelength melanopsin-containing retinal ganglion cells (mRGCs) depolarize and how they affect pupillary constriction induced by light stimulation in humans.The pupil light reflex was evaluated for 30 normal subjects by use of an infrared pupillometer. Blue light stimulation (470 nm) and red light stimulation (635 nm) of 100 cd/m(2) were selected. Selective-wavelength block filters which can selectively remove the wavelengths 440 and 470 nm were used. Visual tests were also performed to observe the effects of the filters on visual acuity, color vision, and contrast sensitivity.The pupil transiently constricts and then settles toward a steady-state diameter when stimulated with the light. When the 470-nm-block filter was worn, the sustained phase of pupillary constriction, thought to be mediated by the mRGCs, was not stable but there was no effect on the initial phase of pupillary constriction under blue light stimulation. Visual acuity, color vision, and contrast sensitivity were not affected by the 470-nm-block filter.These results suggest that the mRGC in humans may respond to 470-nm-wavelength light at 100 cd/m(2), and there is a possibility of affecting the sustained phase of the light reflex without changing visual performance.