Evaluation of sex hormones and sperm parameters in male epileptic patients
Evaluation of sex hormones and sperm parameters in male epileptic patients
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DOI：
10.1111/ane.12892
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发表时间：
2018-04-01
影响因子：
3.5
通讯作者：
Zorlu, Y.
中科院分区：
文献类型：
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作者：
Ocek, L.;Tarhan, H.;Zorlu, Y.
目的探讨卡马西平（CBZ）联合丙戊酸钠（VPA）单药治疗对男性癫痫患者性功能、性激素、精液分析及质量的影响。方法2015年1月至2016年3月共纳入59例男性癫痫患者，其中VPA单药治疗30例，CBZ单药治疗29例。健康男性30名作为对照组。测定各组促黄体生成素（LH）、促卵泡激素（FSH）、催乳素（PRL）、游离睾酮（fT）、雌二醇（E2）、性激素结合球蛋白（SHBG）水平及生物活性睾酮(BAT)/生物活性雌二醇（BAE）、BAT/LH比值。所有组均接受精液分析和国际勃起功能障碍指数（IIEF-5）测试。结果VPA组和CBZ组tse2和DHEAS水平均高于对照组（p < 0.05）。VPA组和CBZ组BAT/BAE比值均较低(P
ObjectivesThe aim of this study was to investigate the effect of carbamazepine (CBZ) and sodium valproate (VPA) monotherapy on sexual functions, sex hormones, and semen analysis and quality in male patients with epilepsy.MethodsA total of 59 male patients with epilepsy, of which 30 were on VPA monotherapy and 29 were on CBZ monotherapy, were included in the study between January 2015 and March 2016. A control group was established with 30 healthy males. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), free testosterone (fT), estradiol (E2), sex hormone-binding globulin (SHBG) levels and bioactive testosterone (BAT)/bioactive estradiol (BAE), and BAT/LH ratio were studied in groups. All groups received semen analysis and International Index of Erectile Function Scale (IIEF-5) test for erectile dysfunction.ResultsE2 and DHEAS levels were higher in VPA and CBZ groups compared to control group (P.05). BAT/BAE ratios were low both in VPA and CBZ groups (P