FDG-PET on irradiated brain tumor: Ten years' summary
FDG-PET on irradiated brain tumor: Ten years' summary
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DOI：
10.1080/02841850500335101
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发表时间：
2006-02-01
期刊：
影响因子：
1.3
通讯作者：
Ericson, K
中科院分区：
文献类型：
--
作者：
Wang, SX;Boethius, J;Ericson, K
目的：评价FDG-PET对放疗后肿瘤复发/恶性变性及放疗后放射反应的鉴别价值，并评价PET对生存的作用。材料和方法：纳入117例连续患者，共156例FDG-PET检查阳性但未诊断的MRI和/或CT。最终诊断基于组织病理学或与放射学和临床随访相关。肺癌脑转移进一步单独研究。生存时间为。用Kaplan-Meier法进行分析。结果：PET真阳性61例，假阳性2例，假阴性15例，真阴性51例；PET阳性5例，阴性22例，不确定。PET检查的阳性预测值为96%，对肺癌脑转移的阳性预测值为100%。组织病理学结果阴性预测值为55.6%。PET阴性患者的生存时间明显延长。结论：FDG-PET是检测肿瘤复发，尤其是肺癌转移的有效工具。FDG摄取是一种预后指标。
Purpose: To evaluate FDG-PET in post-radiotherapy differentiation of tumor recurrence/malignant degeneration and radiation reaction, and to assess the role of PET in terms of survival.Material and Methods: 117 consecutive patients with a total of 156 FDG-PET examinations with positive but non-diagnostic MRI and/or CT were included. Final diagnosis was based on histopathology or correlated with radiologic and clinical follow-up. Brain metastases from lung carcinomas were further studied separately. Survival time was. analysed using the Kaplan-Meier method.Results: There were 61 true-positive, 2 false-positive, 15 false-negative, and 51 true-negative PET examinations; 5 positive and 22 negative PET examinations were indeterminate. The positive predictive value of a PET examination was 96% in all and 100% in brain metastases from lung carcinoma. The negative predictive value based on the histopathologic results was 55.6%. Survival time was significantly longer in patients with negative PET.Conclusion: FDG-PET is a valuable tool in the detection of tumor recurrence, especially lung carcinoma metastasis. FDG uptake is a prognostic marker.