A QUANTITATIVE MAGNETIC-RESONANCE-IMAGING STUDY OF CHANGES IN BRAIN MORPHOLOGY FROM INFANCY TO LATE ADULTHOOD
A QUANTITATIVE MAGNETIC-RESONANCE-IMAGING STUDY OF CHANGES IN BRAIN MORPHOLOGY FROM INFANCY TO LATE ADULTHOOD
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DOI：
10.1001/archneur.1994.00540210046012
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发表时间：
1994-09-01
影响因子：
--
通讯作者：
LIM, KO
中科院分区：
文献类型：
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作者：
PFEFFERBAUM, A;MATHALON, DH;LIM, KO
目的：利用磁共振成像技术（MRI）模拟婴儿到老年期间脑尺寸、灰质、白质和脑脊液（CSF）体积的动态相互关系。设计：采用年龄回归模型的横断面、受试者间研究。环境：退伍军人事务医疗中心和社区医院。参与者：88名年龄在3个月至30岁之间的男性和女性受试者，他们的临床MRI胶片被视为正常，73名年龄在21至70岁之间的健康男性志愿者接受了专门为本研究进行的MRI检查。主要结果测量：这些MRI数据使用半自动计算机技术进行量化，将图像分割为灰质、白质和脑脊液室。在每个分析切片上，以几何方式将皮质定义为外45%，并计算皮质白质、灰质和脑脊液的体积。计算每个分析切片内55%的皮质下（脑室）脑脊液体积。结果：在年轻的样本中，从3个月到10岁，颅内容量增加了约300 mt。在不同年龄的男女中，每个隔室的体积变化模式相同：皮层灰质体积在4岁左右达到峰值，此后下降；皮层白质体积稳步增加，直到20岁左右；皮层和脑脊液体积保持不变。在年龄较大的样本中，通过回归程序对脑容量进行统计调整，以适应头部大小的正常变化，结果显示以下模式：皮层灰质体积呈曲线状早期下降，显示平均体积损失0.7 mL/y，而皮层白质体积在50年内保持不变；在皮质灰质减少的同时，皮质脑脊液体积增加0.6 mL/y，脑室体积增加0.3 mL/y。结论：MRI在体内观察到的这些生长和变化模式与神经病理学研究以及动物发育模型基本一致，可能反映了神经元的进行性和退行性过程，包括细胞生长、髓鞘形成、细胞死亡和萎缩。
Objective: To model in vivo the dynamic interrelations of head size, gray matter, white matter, and cerebrospinal fluid (CSF) volumes from infancy to old age using magnetic resonance imaging (MRI).Design: Cross-sectional, between-subjects using an age-regression model.Setting: A Veterans Affairs medical center and community hospitals.Participants: There were 88 male and female subjects aged 3 months to 30 years whose clinical MRI film had been read as normal and 73 healthy male volunteers aged 21 to 70 years who had an MRI performed specifically for this study.Main Outcome Measures: These MRI data were quantified using a semiautomated computer technique for segmenting images into gray matter, white matter, and CSF compartments. The cortex was defined geometrically as the outer 45% on each analyzed slice, and the volumes of cortical white matter, gray matter, and CSF were computed. Subcortical (ventricular) CSF volume was computed for the inner 55% of each analyzed slice.Results: In the younger sample, intracranial volume increased by about 300 mt from 3 months to 10 years. The same patterns of change in volume of each compartment across the age range were seen in both sexes: cortical gray matter volume peaked around age 4 years and decreased thereafter; cortical white matter volume increased steadily until about age 20 years; cortical and ventricular CSF volumes remained constant. In the older sample, brain volumes were statistically adjusted for normal variation in head size through a regression procedure and revealed the following pattern: cortical gray matter volume decreased curvilinearly, showing an average volume loss of 0.7 mL/y, while cortical white matter volume remained constant during the five decades; complementary to the cortical gray matter decrease, cortical CSF volume increased by 0.6 mL/y and ventricular volumes increased by 0.3 mL/y.Conclusions: These patterns of growth and change seen in vivo with MRI are largely consistent with neuropathological studies, as well as animal models of development, and may reflect neuronal progressive and regressive processes, including cell growth, myelination, cell death, and atrophy.