Pain catastrophizing may moderate the association between pain and secondary hyperalgesia.
Pain catastrophizing may moderate the association between pain and secondary hyperalgesia.
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DOI：
10.1111/jabr.12096
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发表时间：
2017-03
影响因子：
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通讯作者：
A. Pressman;B. Peterlin;D. Tompkins;R. Salas;L. Buenaver;J. Haythornthwaite;C. Campbell
中科院分区：
文献类型：
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作者：
A. Pressman;B. Peterlin;D. Tompkins;R. Salas;L. Buenaver;J. Haythornthwaite;C. Campbell
灾难化是一种以无助、沉思和放大疼痛感为特征的持续性消极心理状态，对疼痛报告和临床结局具有潜在影响。先前的研究已经证明了认知因素和中枢敏感化之间的关联。目前的分析试图测试潜在的调节作用的疼痛灾变辣椒素疼痛和继发性痛觉过敏的区域之间的关联。38名健康个体（50%女性，平均年龄= 25.7，SD = 5.3）完成了疼痛灾难性量表（PCS），然后接受局部应用10%的辣椒素，覆盖在40°C的热电极上，保持90分钟。去除辣椒素后，确定继发性痛觉过敏的区域。Hayes的PROCESS macro被用于检查灾难化的潜在调节作用，其没有揭示辣椒素疼痛评级和继发性痛觉过敏区域之间的显著关联（β = 15.1，p = 0.06）。虽然PCS与继发性痛觉过敏的面积无关（β = 23.9，p = 0.29），但PCS和辣椒素疼痛评分之间存在显著的相互作用（β = 3.7，p = 0.0004）。具体来说，那些赞同更高的灾难化水平和更高的疼痛评级经历了最大的继发性痛觉过敏的领域。Johnson-Neyman技术用于确定调节的区域效应，这表明当PCS评分≥10.6时，辣椒碱疼痛显著调节疼痛与继发性痛觉过敏区域之间的关联。这些结果表明，灾难化在继发性痛觉过敏和潜在的中枢致敏中起着重要作用，在未来的研究中需要进一步的测试。
Catastrophizing, a persistent negative mental set characterized by helplessness, rumination, and magnification of pain sensations, has a potent effect on pain report and clinical outcomes. Previous studies have documented an association between cognitive factors and central sensitization. The current analysis sought to test the potential modulating effect of pain catastrophizing on the association between capsaicin pain and the region of secondary hyperalgesia. Thirty-eight healthy individuals (50% women, mean age = 25.7, SD = 5.3) completed the Pain Catastrophizing Scale (PCS), then underwent topical application of 10% capsaicin, which was covered by a thermode maintained at 40°C for 90-min. Following removal of the capsaicin, the region of secondary hyperalgesia was determined. Hayes' PROCESS macro was employed to examine catastrophizing's potential moderating effect, which did not reveal a significant association between capsaicin pain ratings and the region of secondary hyperalgesia (β = 15.1, p = .06). Though PCS was not associated with area of secondary hyperalgesia (β = 23.9, p = .29), a significant interaction was present between PCS and capsaicin pain ratings (β = 3.7, p = .0004). Specifically, those endorsing higher catastrophizing levels and higher pain ratings experienced the greatest areas of secondary hyperalgesia. The Johnson-Neyman technique was used to determine the regional effect of the moderation, which indicated that when PCS scores were ≥10.6, capsaicin pain significantly moderated the association between pain and area of secondary hyperalgesia. These results suggest that catastrophizing plays an important role in the area of secondary hyperalgesia, and potentially central sensitization, warranting further testing in future research.