Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress
Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress
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DOI：
10.1055/s-0043-119882
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发表时间：
2018-01-01
影响因子：
2.5
通讯作者：
Fabre, Claudine
中科院分区：
文献类型：
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作者：
Bouzid, Mohamed Amine;Filaire, Edith;Fabre, Claudine
通过比较四组人的抗氧化剂活性(超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPX)、谷胱甘肽还原酶(GR)、抗坏血酸和生育酚)和丙二醛水平(MDA)，研究了衰老和规律的体育活动可能影响氧化应激的假说：青年久坐组(n=15；年龄：20.3+/-2.8岁；YS)、年轻活跃组(n=16；年龄：21.4+/-1.9岁；YA)、老年久坐组(n=15；年龄：65.1+/-3.5岁；OS)和老年活动组(n=17；年龄：67.2+/-4.8岁；在静息和递增运动后评估抗氧化剂活性和丙二醛水平。YS和OS在静息抗氧化活性和脂质过氧化方面无明显差异。然而，YA组的静息SOD和GR活性高于OA组(P
The hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid and -Tocopherol) and malondialdehyde level (MDA) in four groups: young sedentary (n=15; age: 20.3 +/- 2.8 years; YS), young active (n=16; age: 21.4 +/- 1.9 years; YA), old sedentary (n=15; age: 65.1 +/- 3.5 years; OS) and old active (n=17; age: 67.2 +/- 4.8 years; OA). Antioxidant activities and MDA level were assessed at rest and after an incremental exercise. There was no difference in resting antioxidant activities and lipid peroxidation between YS and OS. However, resting SOD and GR activities were higher in YA compared to OA (p