AROMATIC AMINE ACETYLTRANSFERASE AS A MARKER FOR COLORECTAL-CANCER - ENVIRONMENTAL AND DEMOGRAPHIC ASSOCIATIONS
AROMATIC AMINE ACETYLTRANSFERASE AS A MARKER FOR COLORECTAL-CANCER - ENVIRONMENTAL AND DEMOGRAPHIC ASSOCIATIONS
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DOI：
10.1002/ijc.2910460107
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发表时间：
1990-07-15
影响因子：
6.4
通讯作者：
LANG, NP
中科院分区：
文献类型：
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作者：
WOHLLEB, JC;HUNTER, CF;LANG, NP
在这项对43名结直肠癌患者和41名对照男性患者进行的先导性病例对照调查中，我们比较了芳香胺乙酰转移酶基因多态性、营养和人口学特征、病史、工业和职业史以及家庭环境和个人习惯暴露与结直肠癌的相关性。具有“快速”乙酰化特征的人患结直肠癌的风险更高(优势比：2.48；95%可信区间：1.02,603)。与以前的报告不同的是，结直肠癌与农业和制造业以及通过吸烟、腌制和烧烤准备的肉类的消费呈正相关。正如预期的那样，运动频率、十字花科蔬菜和膳食纤维作为保护因素。
In this pilot, case-controlled investigation of 43 colorectal and 41 control male patients, we compared associations of colorectal cancer with the aromatic amine acetyltransferase polymorphism, nutritional and demographic characteristics, medical histories, industrial and occupational histories, and exposures from home environments and personal habits. Persons with the "fast" acetylator trait were at greater risk of colorectal cancer (odds ratio: 2.48; 95% confidence interval: 1.02, 603). Results that differed from previous reports were positive associations of colorectal cancer with agricultural and manufacturing industries and with consumption of meats prepared by smoking, curing, and barbecueing. As expected, exercise frequency, cruciferous vegetables, and dietary fiber served as protective factors.