The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the Mesenteric Lymph Node Restrains Intestinal Humoral Immunity
The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the Mesenteric Lymph Node Restrains Intestinal Humoral Immunity
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淋巴组织诱导样细胞与肠系膜淋巴结T细胞的相互作用抑制肠道体液免疫
DOI：
10.1016/j.celrep.2020.107936
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发表时间：
2020-07-21
期刊：
影响因子：
8.8
通讯作者：
Guo, Xiaohuan
中科院分区：
文献类型：
--
作者：
Wang, Wenyan;Li, Yiping;Guo, Xiaohuan
类淋巴组织诱导物（LTi）/LTi样细胞对于各种组织中的淋巴器官发生和适应性免疫的调节至关重要。然而，LTi样细胞在不同组织中的维持和调控机制尚不清楚。在这里，我们发现，LTi样细胞从不同的组织显示异质性。LTi样细胞在肠系膜淋巴结（mLN）而不是肠道中的维持需要来自CD 4（+）T细胞的RANKL信号。来自mLN的LTi样细胞，而不是肠道，可以反过来抑制T滤泡辅助细胞的发育和随后的体液反应，在肠道免疫中以ID 2和PD-L1依赖的方式。总之，我们的研究结果表明，LTi样细胞和T细胞之间的相互作用，在mLN可以精确地控制肠粘膜适应性免疫反应。
Lymphoid tissue inducer (LTi)/LTi-like cells are critical for lymphoid organogenesis and regulation of adaptive immunity in various tissues. However, the maintenance and regulation mechanisms of LTi-like cells among different tissues are not clear yet. Here, we find that LTi-like cells from different tissues display heterogeneity. The maintenance of LTi-like cells in the mesenteric lymph node (mLN), but not the gut, requires RANKL signaling from CD4(+)T cells. LTi-like cells from the mLN, but not the gut, could in turn inhibit the development of T follicular helper cells and subsequent humoral responses during intestinal immunization in an ID2- and PD-L1-dependent manner. Together, our findings implicate that the interaction between LTi-like cells and T cells in the mLN could precisely control the intestinal mucosal adaptive immune response.