Persistent antigenic variation of influenza A viruses after incomplete neutralization in ovo with heterologous immune serum.
Persistent antigenic variation of influenza A viruses after incomplete neutralization in ovo with heterologous immune serum.
复制标题
在OVO中与异源免疫血清不完全中和后，流感病毒的持续性抗原变异。
DOI：
10.1084/jem.92.5.441
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发表时间：
1950-11-01
影响因子：
15.3
通讯作者：
HORSFALL, F L Jr
中科院分区：
文献类型：
--
作者：
ARCHETTI, I;HORSFALL, F L Jr
在具有不同但相关菌株的免疫血清的存在下，流感A病毒菌株的抗原变异在OVO中出现。通过该过程，通过数百种动物通道的旧实验室菌株（PR8）与最近回收的菌株一样很容易修改。显然可以随意获得此类变体，并显示可再现的抗原模式，并且根据其选择的免疫血清似乎可以预测。在没有免疫血清的情况下，变体菌株将其新的抗原模式保留在OVO中的串行通道上。在没有免疫血清的情况下，菌株OVO中的串行序列有限不会导致抗原变异的出现。类似地，在存在免疫血清的菌株中，菌株在针对广泛不同的菌株的存在下，未能表现出明显的跨中和化的串行通道并没有导致抗原变体的出现。
Antigenic variants of influenza A virus strains emerge on serial passage in ovo in the presence of immune serum against different but related strains. An old laboratory strain (PR8) which had been through hundreds of animal passages was as readily modified by this procedure as recently recovered strains. Such variants apparently can be obtained at will and show antigenic patterns which are reproducible and appear to be predictable in terms of the immune serum used for their selection. Variant strains retain their new antigenic patterns on serial passage in ovo in the absence of immune serum. Limited serial passage in ovo of strains in the absence of immune serum did not result in the emergence of antigenic variants. Similarly, serial passages of strains in ovo in the presence of immune serum against widely different strains, which failed to show significant cross-neutralization, did not lead to the appearance of antigenic variants.