A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya.
A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya.
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DOI：
10.1186/1475-2875-7-237
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发表时间：
2008-11-18
期刊：
影响因子：
3
通讯作者：
Kager, Piet A.
中科院分区：
文献类型：
--
作者：
Mens, Petra F.;Sawa, Patrick;van Amsterdam, Sandra M.;Versteeg, Inge;Omar, Sabah A.;Schallig, Henk D. F. H.;Kager, Piet A.
许多国家已实施以青蒿素为基础的联合疗法（ACT）作为疟疾的一线治疗。尽管已经对青蒿素-本芴醇 (AL) 或双氢青蒿素-哌喹 (DP) 组合的功效和耐受性进行了许多研究，但人们对这些药物对配子体发育的影响知之甚少，而配子体发育是疟疾控制中的一个重要问题。在这项双臂随机对照试验中，146 名儿童接受了 AL 或 DP 治疗。两组均接受直接观察治疗，并在治疗后随访 28 天。使用显微镜和 NASBA 分析血液样本。与显微镜相比，NASBA 检测到更多的配子体阳性个体。此外，与 DP 相比，NASBA 在配子体清除方面显示出有利于 AL 的显着差异。 DP 组在第 3、7 和 14 天时寄生虫血症的下降较慢，配子体的持续性或发育明显较高且较长，但 28 天后，两个治疗组之间没有观察到差异。尽管实际考虑可能会倾向于使用一种药物而不是另一种药物，但也应考虑对配子细胞发生的影响，并使用 NASBA 等分子工具进一步研究。当推出新药时这也适用。当前对照试验 ISRCTN36463274
Many countries have implemented artemisinin-based combination therapy (ACT) for the first-line treatment of malaria. Although many studies have been performed on efficacy and tolerability of the combination arthemeter-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP), less is known of the effect of these drugs on gametocyte development, which is an important issue in malaria control. In this two-arm randomized controlled trial, 146 children were treated with either AL or DP. Both groups received directly observed therapy and were followed for 28 days after treatment. Blood samples were analysed with microscopy and NASBA. In comparison with microscopy NASBA detected much more gametocyte positive individuals. Moreover, NASBA showed a significant difference in gametocyte clearance in favour of AL compared to DP. The decline of parasitaemia was slower and persistence or development of gametocytes was significantly higher and longer at day 3, 7 and 14 in the DP group but after 28 days no difference could be observed between both treatment arms. Although practical considerations could favour the use of one drug over another, the effect on gametocytogenesis should also be taken into account and studied further using molecular tools like NASBA. This also applies when a new drug is introduced. Current controlled trials ISRCTN36463274
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影响因子：
2.9
作者：
Sokhna, CS;Trape, JF;Robert, V
通讯作者：
Robert, V
DOI：
10.1371/journal.pctr.0020020
发表时间：
2007-05-18
期刊：
PLoS clinical trials
影响因子：
--
作者：
Kamya, Moses R;Yeka, Adoke;Dorsey, Grant
通讯作者：
Dorsey, Grant
影响因子：
6.4
作者：
Ashley, EA;Krudsood, S;White, NJ
通讯作者：
White, NJ
影响因子：
11.8
作者：
Ashley, EA;McGready, R;Nosten, F
通讯作者：
Nosten, F
影响因子：
15.8
作者：
Sutherland, CJ;Ord, R;Targett, GAT
通讯作者：
Targett, GAT