Synchrony of auditory brain responses predicts behavioral ability to keep still in children with autism spectrum disorder: Auditory-evoked response in children with autism spectrum disorder.
Synchrony of auditory brain responses predicts behavioral ability to keep still in children with autism spectrum disorder: Auditory-evoked response in children with autism spectrum disorder.
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DOI：
10.1016/j.nicl.2016.07.009
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Minabe Y
中科院分区：
文献类型：
--
作者：
Yoshimura Y;Kikuchi M;Hiraishi H;Hasegawa C;Takahashi T;Remijn GB;Oi M;Munesue T;Higashida H;Minabe Y
脑磁图记录的听觉诱发的P1 m反映了人类儿童的中枢听觉处理能力。最近的一项研究表明，左右半球之间的P1 m的差异反映了中枢听觉处理障碍（即，注意力缺陷多动障碍（ADHD）。然而，到目前为止，听觉P1 m左右半球同步化与自闭症谱系障碍（ASD）儿童多动共病之间的关系尚不清楚。本研究在以往ADHD儿童P1 m检测的基础上，探讨ASD儿童P1 m左右半球同步化与多动的关系，以探讨ASD儿童P1 m左右半球同步化与多动的关系。除了同步化，我们还研究了左右半球的偏侧化。我们的研究结果未能证明这些值之间的显着差异ASD儿童和没有多动症的症状，这是使用自闭症诊断观察计划，通用（ADOS-G）子量表进行评估。然而，在12分钟的脑磁图记录期间，大脑半球同步化的程度和保持静止的能力之间存在显著的相关性。我们的研究结果还表明，双侧大脑听觉处理系统中的神经元与ASD儿童的ADHD样症状有关。听觉诱发的P1 m反映了儿童的中枢听觉加工能力。本研究揭示了P1 m与ASD儿童多动的关系。在脑磁图测量过程中，大脑半球的同步化与保持静止的能力之间存在相关性。右半球较短的P1 m潜伏期与多动相关。大脑听觉处理的不同步性预测ASD儿童的合并症
The auditory-evoked P1m, recorded by magnetoencephalography, reflects a central auditory processing ability in human children. One recent study revealed that asynchrony of P1m between the right and left hemispheres reflected a central auditory processing disorder (i.e., attention deficit hyperactivity disorder, ADHD) in children. However, to date, the relationship between auditory P1m right-left hemispheric synchronization and the comorbidity of hyperactivity in children with autism spectrum disorder (ASD) is unknown. In this study, based on a previous report of an asynchrony of P1m in children with ADHD, to clarify whether the P1m right-left hemispheric synchronization is related to the symptom of hyperactivity in children with ASD, we investigated the relationship between voice-evoked P1m right-left hemispheric synchronization and hyperactivity in children with ASD. In addition to synchronization, we investigated the right-left hemispheric lateralization. Our findings failed to demonstrate significant differences in these values between ASD children with and without the symptom of hyperactivity, which was evaluated using the Autism Diagnostic Observational Schedule, Generic (ADOS-G) subscale. However, there was a significant correlation between the degrees of hemispheric synchronization and the ability to keep still during 12-minute MEG recording periods. Our results also suggested that asynchrony in the bilateral brain auditory processing system is associated with ADHD-like symptoms in children with ASD. The auditory-evoked P1m reflects a central auditory processing ability in children. This study showed the relationship between P1m and hyperactivity in ASD children. There was a correlation between hemispheric synchronization and the ability to keep still during MEG measurement. A shorter P1m latency in the right hemisphere was associated with hyperactivity. Asynchrony in the brain auditory processing predicts the comorbidity in children with ASD.