Pediatric Cerebral Malaria.
Pediatric Cerebral Malaria.
复制标题
小儿脑型疟疾。
DOI：
10.1007/s40475-021-00227-4
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发表时间：
2021-06
影响因子：
5.4
通讯作者：
Postels D
中科院分区：
文献类型：
--
作者：
Guenther G;Muller D;Moyo D;Postels D
综述目的疟疾是人类最重要的寄生虫病。脑型疟疾是疟疾最致命的临床表现，对流行地区的公共卫生产生深远影响。在非洲，它主要是一种儿童疾病。在这里，我们回顾了脑型疟疾发病机制、临床护理、治疗和预防方面的最新研究进展。最新发现全球范围内疟疾发病率正在下降，尽管大部分下降发生在 2014 年之前。临床上，磁共振成像显示的脑体积大幅增加与脑型疟疾儿童的死亡率密切相关。了解哪些病理生理变化导致这些磁共振成像结果可能有助于更好地设计有针对性的干预措施的临床试验，从而降低脑型疟疾幸存者的死亡率和神经发病率。包括疫苗接种在内的预防策略有望减少该疾病对公共卫生的影响。摘要随着科学更好地了解疟疾感染、昏迷和不良后果之间的关键病理生理步骤，针对疾病过程中关键步骤的辅助疗法临床试验的合理设计将成为可能。与此同时，预防策略，包括候选疫苗的设计和测试，必须继续下去。
Purpose of ReviewMalaria is the most important parasitic disease of humankind. Cerebral malaria is malaria’s deadliest clinical manifestation and has a profound public health impact in endemic areas. In Africa, it is primarily a disease of childhood. Here we review recent updates in research into cerebral malaria pathogenesis, clinical care, treatment, and prevention.Recent FindingsMalaria incidence is declining world-wide, though most of the decreases occurred prior to 2014. Clinically, highly increased brain volume on magnetic resonance imaging is strongly associated with mortality in children with cerebral malaria. Understanding which pathophysiological changes are responsible for these magnetic resonance imaging findings may lead to better design of clinical trials of targeted interventions that could lead to reductions in both mortality and neurological morbidity in cerebral malaria survivors. Prevention strategies, including vaccination, hold great promise to decrease the disease’s public health impact.SummaryAs science better understands the key pathophysiological steps between malaria infection, coma, and adverse outcomes, rational design of clinical trials of adjunctive therapies targeting key steps in the disease process will be possible. In the meantime, prevention strategies, including design and testing of candidate vaccines, must continue.
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影响因子：
48
作者：
Birbeck, Gretchen L.;Molyneux, Malcolm E.;Taylor, Terrie E.
通讯作者：
Taylor, Terrie E.
影响因子：
3
作者：
Issiaka, Djibrilla;Barry, Amadou;Dicko, Alassane
通讯作者：
Dicko, Alassane
DOI：
10.1073/pnas.1521077112
发表时间：
2015-12-08
影响因子：
11.1
作者：
Gantz, Valentino M.;Jasinskiene, Nijole;James, Anthony A.
通讯作者：
James, Anthony A.
影响因子：
3
作者：
Hawkes, Michael T.;Conroy, Andrea L.;Kain, Kevin C.
通讯作者：
Kain, Kevin C.
影响因子：
4.6
作者：
Joshi V;Agurto C;Barriga S;Nemeth S;Soliz P;MacCormick IJ;Lewallen S;Taylor TE;Harding SP
通讯作者：
Harding SP