Quinolinic acid in the cerebrospinal fluid of children after traumatic brain injury
Quinolinic acid in the cerebrospinal fluid of children after traumatic brain injury
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DOI：
10.1097/00003246-199903000-00023
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发表时间：
1999-03-01
影响因子：
8.8
通讯作者：
Adelson, PD
中科院分区：
文献类型：
--
作者：
Bell, MJ;Kochanek, PM;Adelson, PD
目的：为了测量创伤性脑损伤（TBI）后儿童脑脊液（CSF）中的喹啉酸（一种巨噬细胞源性神经毒素），并将CSF喹啉酸浓度与临床重要变量相关联。设计：一项前瞻性观察性研究。设置：匹兹堡儿童医院的儿科重症监护室，一家三级护理，大学儿童医院。患者：17例重症TBI患儿（格拉斯哥昏迷量表评分
Objective: To measure quinolinic acid, a macrophage-derived neurotoxin, in the cerebrospinal fluid (CSF) of children after traumatic brain injury (TBI) and to correlate CSF quinolinic acid concentrations to clinically important variables.Design: A prospective, observational study.Setting: The pediatric intensive care unit in Children's Hospital of Pittsburgh, a tertiary care, university based children's hospital.Patients: Seventeen critically ill children following severe TBI (Glasgow Coma Scale score