C-reactive protein is associated with heart rate variability
C-reactive protein is associated with heart rate variability
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DOI：
10.1111/j.1542-474x.2007.00164.x
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发表时间：
2007-07-01
影响因子：
1.9
通讯作者：
Schmidt, Erik Berg
中科院分区：
文献类型：
--
作者：
Madsen, Trine;Christensen, Jeppe Hagstrup;Schmidt, Erik Berg
背景：本研究的目的是探讨低度炎症和自主神经功能障碍之间的关系，这两者都可能是心源性猝死的危险标志。方法：269例临床疑似冠心病患者择期行冠状动脉造影。其中27%有心肌梗塞病史，70%有明显的冠状动脉狭窄。所有受试者均获得24小时动态心电图记录，并分析时域心率变异性指数。采用高灵敏度测定法测定c反应蛋白。结果：与高hs-CRP四分位数相比，低四分位数的平均SDNN显著高于高四分位数（140 +/- 34 ms vs 113 +/- 29 ms; P < 0.001）。sdn指数（54 +/- 16 ms vs 46 +/- 12 ms, P = 0.002）和SDANN （125 +/- 33 ms vs 101 +/- 31 ms, P < 0.001）也发现了类似的结果。这种相关性在既往有心肌梗死、有明显冠状动脉狭窄和男性的受试者中最强。在线性回归分析中，hs-CRP仍然是这三个心率变异性指标的独立决定因素（均P < 0.001）。结论：c反应蛋白与心率变异性独立相关。这可能支持低度炎症和自主神经功能障碍之间的联系。
Background: The aim of this study was to investigate the relation between low-grade inflammation and autonomic dysfunction, both of which may be risk markers for sudden cardiac death.Methods: A total of 269 subjects referred for elective coronary angiography because of clinically suspected coronary heart disease were included in the study. Of these 27% had a previous myocardial infarction and 70% had significant coronary stenoses. A 24-hour Holter-recording was obtained from all subjects, and time-domain heart rate variability indices were analyzed. C-reactive protein was measured using a high-sensitivity assay.Results: Mean SDNN was significantly higher in the lower compared to the upper hs-CRP quartile (140 +/- 34 ms vs 113 +/- 29 ms; P < 0.001). Similar results were found for SDNNindex (54 +/- 16 ms vs 46 +/- 12 ms; P = 0.002) and SDANN (125 +/- 33 ms vs 101 +/- 31 ms; P < 0.001). The association was strongest for subjects with a previous myocardial infarction, subjects with significant coronary stenoses, and males. In a linear regression analysis, hs-CRP remained an independent determinant of each of these three heart rate variability indices (all P < 0.001).Conclusion: C-reactive protein and heart rate variability are independently associated. This may support a link between low-grade inflammation and autonomic dysfunction.