Synchronization of fast (30-40 Hz) spontaneous oscillations in intrathalamic and thalamocortical networks
Synchronization of fast (30-40 Hz) spontaneous oscillations in intrathalamic and thalamocortical networks
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DOI：
10.1523/jneurosci.16-08-02788.1996
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发表时间：
1996-04
期刊：
影响因子：
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通讯作者：
M. Steriade;D. Contreras;F. Amzica;lgor Timofeev
中科院分区：
文献类型：
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作者：
M. Steriade;D. Contreras;F. Amzica;lgor Timofeev
在氯胺酮-甲苯噻嗪麻醉下和行为动物中，通过场电位、丘脑网状核（RE）、丘脑背核（感觉核、运动核和板内核）和相关新皮层区多个位点的细胞外和细胞内记录，研究了猫丘脑内和丘脑皮质（TC）网络快速（主要为30 - 40 Hz）振荡的同步性。快速振荡不仅限于紧张性激活的行为状态，而且也出现在静息睡眠和深度麻醉期间，当它们发生在缓慢（<1 Hz）振荡的去极化分量上时，并且在RE、TC和皮质神经元的长时间超极化期间受到抑制。不同丘脑病灶之间的快节奏同步是强大的。快速节奏的皮层波和阈下去极化电位在TC神经元是高度一致的，但是，同步的快速振荡需要记录从神经元相关的新皮层和丘脑病灶，确定在两个方向的单突触反应。相干快节律的短程空间限制与低频睡眠节律的大范围同步形成对比。短暂的快节奏，出现在去极化信封的缓慢睡眠振荡，成为持续的大脑激活时，引起的刺激中脑脑桥胆碱能核或在大脑活动的行为状态在慢性实验。这些数据表明，快节奏是大脑的背景电活动的一部分，并且用于指定大脑活动状态的去振荡是一个错误的术语，因为快速振荡不仅在皮质内同步，而且在丘脑内和TC网络中同步。
The synchronization of fast (mainly 30 to 40 Hz) oscillations in intrathalamic and thalamocortical (TC) networks of cat was studied under ketamine-xylazine anesthesia and in behaving animals by means of field potential, extra- and intracellular recordings from multiple sites in the thalamic reticular (RE) nucleus, dorsal (sensory, motor, and intralaminar) thalamic nuclei, and related neocortical areas. Far from being restricted to tonically activated behavioral states, the fast oscillations also appeared during resting sleep and deep anesthesia, when they occurred over the depolarizing component of the slow (<1 Hz) oscillation and were suppressed during the prolonged hyper- polarizations of RE, TC, and cortical neurons. The synchronization of fast rhythms among different thalamic foci was robust. Fast rhythmic cortical waves and subthreshold depolarizing potentials in TC neurons were highly coherent; however, the synchronization of the fast oscillation required recordings from reciprocally related neocortical and thalamic foci, as identified by monosynaptic responses in both directions. The short-range spatial confinement of coherent fast rhythms contrasted with the large-scale synchronization of low- frequency sleep rhythms. Transient fast rhythms, appearing over the depolarizing envelope of the slow sleep oscillation, became sustained when brain activation was elicited by stimulation of mesopontine cholinergic nuclei or during brain-active behavioral states in chronic experiments. These data demonstrate that fast rhythms are part of the background electrical activity of the brain and that desynchronization, used to designate brain-active states, is an erroneous term inasmuch as the fast oscillations are synchronized not only in intracortical but also in intrathalamic and TC networks.