Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects
Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects
复制标题
DOI：
10.1016/j.orcp.2009.09.007
复制
发表时间：
2010-04-01
影响因子：
4.3
通讯作者：
Araki, Eiichi
中科院分区：
文献类型：
--
作者：
Kondo, Tatsuya;Sasaki, Kazunari;Araki, Eiichi
目的：肥胖引起慢性炎症，参与胰岛素抵抗、糖尿病和动脉粥样硬化的发生和发展。我们最近的研究表明，在2型糖尿病小鼠模型中，通过轻度电流和热（MET）处理诱导热休克蛋白72可以改善葡萄糖稳态和胰岛素抵抗，同时减少肥胖。对于MET的临床应用，我们证实了其在健康受试者中的安全性。方法：对10名健康日本男性进行MET (12 V， 55脉冲/s， 42℃，30 min)，每周2次，连续8周。通过CT扫描测量脂肪体积，并对几个参数进行了研究。结果：MET未引起任何不良反应或肌肉收缩/疼痛。葡萄糖稳态或胰岛素抵抗没有明显改变。内脏和皮下脂肪体积呈下降趋势，但差异无统计学意义（分别为-3.9%和-4.3%），在停药8周后恢复。有趣的是，血清肿瘤坏死因子- α (tnf - α: 0.91 +/- 0.05 pg/mL vs. 0.67 +/- 0.06 pg/mL, p = 0.006)和高敏c反应蛋白（hs-CRP: 521.9 +/- 73.9 ng/mL vs. 270.8 +/- 43.7 ng/mL, p = 0.023）水平均显著降低，两者均与慢性炎症相关。结论：MET可能有助于减少糖尿病和代谢综合征患者的炎症反应。(C) 2009年亚洲大洋洲肥胖研究协会。Elsevier Ltd.出版。版权所有。
Objective: Obesity induces chronic inflammation, which contributes to the development and progression of insulin resistance, diabetes and atherosclerosis.We have recently shown that induction of heat shock protein 72 by mild electric current and thermo (MET) treatment in mouse model of type 2 diabetes ameliorated glucose homeostasis and insulin resistance accompanied by reduced adiposity. For clinical application of MET, we confirmed its safety in healthy subjects.Methods: MET was applied for 10 healthy Japanese male (12 V, 55 pulses/s, 30 min at 42 degrees C) twice a week for 8 weeks. Fat volume was measured by CT scan and several parameters were investigated.Results: MET did not induce any adverse effects nor muscle contraction/pain. There were no significant alterations in glucose homeostasis or insulin resistance. Visceral and subcutaneous fat volume showed a trend of decrease without significant difference (-3.9% and -4.3%, respectively), which were restored 8 weeks after withdrawal of MET. Interestingly, serum tumor necrosis factor-alpha (TNF-alpha: 0.91 +/- 0.05 pg/mL vs. 0.67 +/- 0.06 pg/mL; p = 0.006) and high sensitivity C-reactive protein (hs-CRP: 521.9 +/- 73.9 ng/mL vs. 270.8 +/- 43.7 ng/mL; p = 0.023) levels, both of which are associated with chronic inflammation, were significantly decreased.Conclusion: MET may be beneficial for the reduction of an inflammatory response observed in diabetes and metabolic syndrome. (C) 2009 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.