Physical activity and risk of vasomotor symptoms in women with and without a history of depression: results from the Harvard Study of Moods and Cycles.
Physical activity and risk of vasomotor symptoms in women with and without a history of depression: results from the Harvard Study of Moods and Cycles.
复制标题
有或没有抑郁症病史的女性的体力活动和血管舒缩症状的风险：哈佛情绪和周期研究的结果。
DOI：
10.1097/01.gme.0000227332.43243.00
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Harlow,BernardL
中科院分区：
文献类型：
--
作者：
Thurston,RebeccaC;Joffe,Hadine;Soares,ClaudioN;Harlow,BernardL
Objective:To examine whether physical activity was associated with decreased risk of vasomotor symptoms in a prospective study of women transitioning through menopause.Design:Hypotheses were evaluated in the Harvard Study of Moods and Cycles, a longitudinal study of women with and without a history of major depression (N= 523). Ordinal logistic regression models were utilized to assess the odds of vasomotor symptoms (none, mild, moderate/severe; Greene Climacteric Scale) associated with physical activity (quartiles of metabolic equivalent-hours per week) at study enrollment and over a 3-to 5-year follow-up period.Results:No significant associations between physical activity and vasomotor symptoms were observed for the sample as a whole. However, exploratory analyses stratified by depression history revealed that among the 157 women with a lifetime history of major depression, high (odds ratio [OR]= 0.28, 95% CI: 0.09-0.83) or moderately high (OR= 0.33, 95% CI: 0.11-0.99) physical activity proximal to the vasomotor assessment, as well as consistently high (OR= 0.27, 95% CI: 0.10-0.75) or increasing (OR= 0.33, 95% CI: 0.12-0.92) physical activity over the duration of the 3-to 5-year follow-up period was associated with decreased vasomotor symptoms relative to sedentary behavior. No significant associations were observed for women without a history of depression.Conclusions:Physical activity may be associated with decreased risk of vasomotor symptoms among women with a history of major depression.
