Oxidative cross-dehydrogenative coupling between N-aryl tetrahydroisoquinolins and 5H-oxazol-4-ones through two methodologies: copper catalysis or a metal-free strategy.
Oxidative cross-dehydrogenative coupling between N-aryl tetrahydroisoquinolins and 5H-oxazol-4-ones through two methodologies: copper catalysis or a metal-free strategy.
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DOI：
10.1039/c4cc04508d
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发表时间：
2014-11
影响因子：
4.9
通讯作者：
Xihong Liu;Jinlong Zhang;Shixiong Ma;Yunxia Ma;Rui Wang
中科院分区：
文献类型：
--
作者：
Xihong Liu;Jinlong Zhang;Shixiong Ma;Yunxia Ma;Rui Wang
以空气为唯一氧化剂，溴化亚铜催化N-芳基四氢异喹啉与5-恶唑-4-酮的直接氧化交叉脱氢偶联反应，该反应在无金属氧化体系中也能顺利进行。以较高的产率和良好的非对映选择性合成了一系列烷基化四氢异喹啉衍生物。
A direct oxidative cross-dehydrogenative coupling (CDC) of N-aryl tetrahydroisoquinolins with 5H-oxazol-4-ones catalyzed by CuBr using air as the only oxidant has been developed, which could also proceed smoothly under a metal-free oxidative system with PhI(OAc)2 as the oxidant. A series of alkylated tetrahydroisoquinolin derivatives were obtained in good yields and excellent diastereoselectivities.