Cardiac Force and Muscle Shortening in Regional Ischemia: Asynchronization and Possible Uncoupling
Cardiac Force and Muscle Shortening in Regional Ischemia: Asynchronization and Possible Uncoupling
复制标题
局部缺血中的心脏力量和肌肉缩短：不同步和可能的解耦
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
J. Kedem
中科院分区：
文献类型：
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作者：
J.K. Li;Ying Zhu;X. Guan;G. Drzewiecki;J. Kedem
急性心肌缺血影响受影响区域的心肌力量发育和缩短。具体机制尚不清楚。我们通过实验和肌纤维模型研究了缺血和再灌流期间的心肌功能。模型在收缩和力激活方面受到摄动。结果表明，心肌模型反映了心肌缺血和再灌流过程中观察到的许多生理变化。在局部缺血和再灌流中观察到的力量产生和肌肉缩短之间的不同步可能取决于它们解偶联的程度
Acute myocardial ischemia affects both cardiac muscle force development and shortening in the affected regions. The exact mechanisms are unclear. We investigated myocardial function during ischemia and reperfusion both experimentally and with a muscle fiber model. The model was subjected to perturbations in contractility and force activation. Results show that the cardiac muscle model reflects many of the physiological changes observed in myocardial ischemia and reperfusion. Asynchronization between force generation and muscle shortening observed during regional ischemia and reperfusion may be dependent on the extent of their uncoupling
区域心肌力传感器的新颖设计。
影响因子：
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作者：
Wang,JJ;Drzewiecki,G;Li,JK;Kedem,J
通讯作者：
Kedem,J