Immunophenotypic Profiles in Polycystic Ovary Syndrome
Immunophenotypic Profiles in Polycystic Ovary Syndrome
复制标题
多囊卵巢综合征的免疫表型特征
DOI：
10.1155/2020/5894768
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发表时间：
2020-03-19
影响因子：
4.6
通讯作者：
Yi, Huanfa
中科院分区：
文献类型：
--
作者：
Hu, Cong;Pang, Bo;Yi, Huanfa
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Polycystic ovary syndrome (PCOS) a long-known endocrinopathy and one of the most common endocrine-reproductive-metabolic disorders in women, which can lead to infertility. Although the precise etiology remains unclear, PCOS is considered as a complex genetic trait, with a high degree of heterogeneity. Besides, hormones and immune cells, including both innate and adaptive immune cells, are reportedly a cross talk in PCOS. Chronic low-grade inflammation increases autoimmune disease risk. This proinflammatory condition may, in turn, affect vital physiological processes that ultimately cause infertility, such as ovulation failure and embryo implantation. Here, we review the accumulating evidence linking PCOS with inflammatory status providing an overview of the underlying hormone-mediated dysregulation of immune cells. We mainly focus on the correlational evidence of associations between immune status in women and the increased prevalence of PCOS, along with the specific changes in immune responses. Further recognition and exploration of these interactions may help elucidate PCOS pathophysiology and highlight targets for its treatment and prevention.