NHC-catalyzed regiodivergent syntheses of difunctionalized 3-pyrazolidinones from alpha-bromoenal and monosubstituted hydrazine
NHC-catalyzed regiodivergent syntheses of difunctionalized 3-pyrazolidinones from alpha-bromoenal and monosubstituted hydrazine
复制标题
NHC 催化从 α-溴烯醛和单取代肼区域差异合成双官能化 3-吡唑烷酮
DOI：
10.1039/c7ob02041d
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发表时间：
2017
影响因子：
3.2
通讯作者：
Yao Changsheng
中科院分区：
文献类型：
--
作者：
Yu Chenxia;Shen Shide;Jiang Ligen;Li Jing;Lu Yumiao;Li Tuanjie;Yao Changsheng
通过调节N-杂环卡宾（NHC）催化剂的结构，α-溴烯醛与单取代肼的[3 + 2]成环反应可以区域差异地得到1，5或2，5-双官能化的3-吡唑烷酮。中到高的产率，温和的反应条件，良好的区域选择性和潜在的生物意义的最终产品，使该协议的吸引力的组装3-吡唑烷酮。
A formal [3 + 2] annulation of α-bromoenal with monosubstituted hydrazine could give 1,5 or 2,5-difunctionalized 3-pyrazolidinone regiodivergently by tuning the structure of the N-Heterocyclic Carbene (NHC) catalyst. Moderate to high yields, mild reaction conditions, good regioselectivity and potential biological significance of the final product have made this protocol attractive for the assembly of 3-pyrazolidinone.