In vivo determination of human breast fat composition by 1H magnetic resonance spectroscopy at 7 T
In vivo determination of human breast fat composition by 1H magnetic resonance spectroscopy at 7 T
复制标题
DOI：
10.1002/mrm.22993
复制
发表时间：
2012-01-01
影响因子：
3.3
通讯作者：
Malloy, Craig R.
中科院分区：
文献类型：
--
作者：
Dimitrov, Ivan E.;Douglas, Deborah;Malloy, Craig R.
饮食和脂肪消耗在乳腺癌发病机制中的作用是一个重要课题。我们报告了一种通过 7 T 质子磁共振波谱 (MRS) 无创测定人类乳腺脂质成分的方法。对 10 名健康志愿者的脂肪组织进行两次呼吸触发 TE 平均受激回波采集模式 (STEAM) 采集，其中第二次采集所有梯度都反转。该采集协议可以抑制调制边带，从而使短 TEavg = 24.5 ms 时的频谱分析变得复杂。整个采集过程大约需要 10 分钟。通常可以解析十个脂质峰。还测量了 T1 和 T2，并用于校正峰值 +/- 8.4%，单不饱和峰值为 48.5 +/- 7.9%，多不饱和峰值为 22.7 +/- 3.1%，与皮下脂肪测量报告的值非常一致。饱和、单不饱和和多不饱和部分的受试者内变异性分别为 2.0%、1.6% 和 3.6%。总之，我们已经证明，可以通过 7 T 的质子 MRS 非常简单、快速且无创地对乳腺组织中的脂质进行化学分析。Magn Reson Med，2011。(C) 2011 Wiley-Liss, Inc.
The role of diet and fat consumption in the pathogenesis of breast cancer is an important subject. We report a method for noninvasive determination of lipid composition in human breast by proton magnetic resonance spectroscopy (MRS) at 7 T. Two respiratory-triggered TE-averaged stimulated echo acquisition mode (STEAM) acquisitions were performed on the adipose tissue of 10 healthy volunteers where the second acquisition had all gradients inverted. This acquisition protocol allows the suppression of modulation sidebands that complicate spectral analysis at the short TEavg = 24.5 ms. The entire acquisition takes similar to 10 min. Ten lipid peaks were typically resolved. T1 and T2 were also measured and used to correct the peak +/- 8.4%, monounsaturated, 48.5 +/- 7.9%, and polyunsaturated, 22.7 +/- 3.1%, in close agreement with reported values from subcutaneous adipose measurements. Intrasubject variability was 2.0, 1.6, and 3.6% for the saturated, monounsaturated, and polyunsaturated fractions, respectively. In conclusion, we have shown that a chemical analysis of lipids in breast tissue can be determined quite simply, quickly, and noninvasively by proton MRS at 7 T. Magn Reson Med, 2011. (C) 2011 Wiley-Liss, Inc.