Diabetes-associated complications in Spontaneously Diabetic Torii fatty rats
Diabetes-associated complications in Spontaneously Diabetic Torii fatty rats
复制标题
DOI：
10.1538/expanim.57.111
复制
发表时间：
2008-04-01
影响因子：
2.4
通讯作者：
Matsushita, Mutsuyoshi
中科院分区：
文献类型：
--
作者：
Matsui, Kenichi;Ohta, Takeshi;Matsushita, Mutsuyoshi
将Zucker肥胖大鼠的fa等位基因导入自发性糖尿病鸟（Spontaneous Diabetic Torii，SDT）大鼠基因组，建立了一种新的肥胖2型糖尿病模型。与SDT-+/+（SDT正常）大鼠相比，SDT-fa/fa（SDT脂肪）大鼠表现出明显的肥胖，并且在年轻时观察到高血糖和高血脂。然而，SDT肥胖大鼠糖尿病并发症的特点还未见报道。在本研究中，糖尿病并发症的发生率和进展的SDT脂肪大鼠进行了检查，并与SDT正常大鼠进行了比较。SDT肥胖大鼠的血尿素氮、尿量和尿蛋白等肾功能指标从4周龄开始增加，8周龄开始观察肾小管的病理改变。此外，从8周龄开始在SDT脂肪大鼠中观察到白内障，并且在16和24周龄时观察到视网膜电图上的峰值延迟。另一方面，在SDT正常大鼠中，从24周龄开始观察到肾脏或眼部变化。随着糖尿病的早期发病，SDT肥胖大鼠中的糖尿病相关并发症比SDT正常大鼠中的糖尿病相关并发症在更年轻的年龄观察到。结论：SDT肥胖大鼠有望成为分析糖尿病并发症和评价代谢性疾病相关药物的有用模型。
The Spontaneously Diabetic Torii (SDT) fatty rat, established by introducing the fa allele of the Zucker fatty rat into the SDT rat genome, is a new model of obese type 2 diabetes. The SDT-fa/fa (SDT fatty) rat shows overt obesity, and hyperglycemia and hyperlipidemia are observed at a young age as compared with the SDT-+/+ (SDT normal) rat. However, the features of the diabetic complications in the SDT fatty rat have not been reported. In the present study, the incidence and the progression of diabetic complications in the SDT fatty rat were examined, and compared with those of the SDT normal rat. Renal function parameters, such as blood urea nitrogen, urine volume and urinary protein, increased from 4 weeks of age in the SDT fatty rat, and pathological findings in the renal tubule were observed from 8 weeks. Furthermore, cataract was observed in the SDT fatty rat from 8 weeks of age, and prolongation of peak latencies on electroretinograms was observed at 16 and 24 weeks of age. On the other hand, in the SDT normal rat, renal or ocular changes were observed from 24 weeks of age. With early incidence of diabetes mellitus, diabetes-associated complications in the SDT fatty rat were seen at younger ages than those in the SDT normal rat. In conclusion, the SDT fatty rat is expected to be a useful model for the analysis of diabetic complications and the evaluation of drugs related to metabolic diseases.