Role of Endogenous Testosterone Concentration in Pediatric Stroke
Role of Endogenous Testosterone Concentration in Pediatric Stroke
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DOI：
10.1002/ana.21840
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发表时间：
2009-12-01
影响因子：
11.2
通讯作者：
Nowak-Goettl, Ulrike
中科院分区：
文献类型：
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作者：
Normann, Sandra;de Veber, Gabrielle;Nowak-Goettl, Ulrike
先前的研究表明，男性在儿童中风中占主导地位。为了阐明这种性别差异，我们测量了动脉缺血性中风儿童 (AIS；n = 72)、脑静脉血栓形成儿童 (CSVT；n = 52) 和 109 名健康对照儿童的总睾酮浓度。 10 名 AIS 儿童（13.9%）和 10 名 CSVT 儿童（19.2%）的睾酮水平高于年龄和性别的第 90 个百分位数，总共占脑血栓栓塞患者的 16.7%，而 109 名对照中只有 2 名（1.8%；p = 0.002）。在调整总胆固醇水平、血细胞比容和青春期状态的多变量分析中，睾酮升高与疾病风险增加独立相关（优势比[95%置信区间]：总体 = 3.98 [1.38-11.45]；AIS = 3.88 [1.13-13.35]；CSVT = 5.50 [1.65-18-32]）。进一步调整分析显示，男孩睾酮水平每增加1nmol/l，脑血栓栓塞的几率就会增加1.3倍。安·尼罗尔 2009；66:754-758
Previous studies have indicated a male predominance in pediatric stroke. To elucidate this gender disparity, total testosterone concentration was measured in children with arterial ischemic stroke (AIS; n = 72), children with cerebral sinovenous thrombosis (CSVT; n = 52), and 109 healthy controls. Testosterone levels above the 90th percentile for age and gender were documented in 10 children with AIS (13.9%) and 10 with CSVT (19.2%), totaling 16.7% of patients with cerebral thromboembolism overall, as compared with only 2 of 109 controls (1.8%; p = 0.002). In multivariate analysis with adjustment for total cholesterol level, hematocrit, and pubertal status, elevated testosterone was independently associated with increased disease risk (odds ratio [95% confidence interval]: overall = 3.98 [1.38-11.45]; AIS = 3.88 [1.13-13.35]; CSVT = 5.50 [1.65-18-32]). Further adjusted analyses revealed that, for each 1nmol/l increase in testosterone in boys, the odds of cerebral thromboembolism were increased 1.3-fold. Ann Neurol 2009;66:754-758