Asymmetric Catalytic Aziridination of Cyclic Enones
Asymmetric Catalytic Aziridination of Cyclic Enones
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DOI：
10.1002/asia.201000040
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发表时间：
2010-01-01
影响因子：
4.1
通讯作者：
Melchiorre, Paolo
中科院分区：
文献类型：
--
作者：
De Vincentiis, Francesco;Bencivenni, Giorgio;Melchiorre, Paolo
首次报道了环烯酮不对称氮丙啶化反应的催化方法。所提出的有机催化策略是基于使用一种容易获得的有机催化剂，该催化剂能够将宽范围的环状烯酮转化为具有非常高的对映体纯度和良好的化学产率的所需氮杂环丙烷。这种方法很可能为立体选择性地制备具有茚满部分的复杂手性分子开辟了新的机会，茚满部分是在大量生物活性和药学上重要的分子中发现的框架
The first catalytic method for the asymmetric aziridination of cyclic enones is described. The presented organocatalytic strategy is based on the use of an easily available organocatalyst that is able to convert a wide range of cyclic enones into the desired aziridines with very high enantiomeric purity and good chemical yield. Such a method may very well open up new opportunities to stereoselectively prepare complex chiral molecules that possess an indane moiety, a framework that is found in a large number of bioactive and pharmaceutically important molecules