FKBP5 polymorphisms and antidepressant response in geriatric depression.
FKBP5 polymorphisms and antidepressant response in geriatric depression.
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DOI：
10.1002/ajmg.b.31019
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发表时间：
2010-03-05
影响因子：
2.8
通讯作者：
Murphy, Greer M., Jr.
中科院分区：
文献类型：
--
作者：
Sarginson, Jane E.;Lazzeroni, Laura C.;Ryan, Heather S.;Schatzberg, Alan F.;Murphy, Greer M., Jr.
在几项研究中，FKBP 5基因座的遗传变异已被报道会影响接受抗抑郁药物治疗的患者的临床结局。然而，其他报告并未证实这种关联。FKBP 5可能调节下丘脑-垂体-肾上腺轴的敏感性。我们在一项帕罗西汀和米氮平的双盲随机对照试验中检测了246例接受8周治疗的老年患者的两种FKBP 5单核苷酸多态性（rs 1360780和rs3800373）。这两种多态性以前曾被报道可预测用选择性5-羟色胺再摄取抑制剂（如帕罗西汀）治疗的抑郁症患者和用米氮平（一种同时具有肾上腺素能和去甲肾上腺素能作用的药物）治疗的抑郁症患者的疗效。然而，我们发现这些FKBP 5基因变异与临床结果之间没有显著相关性。FKBP 5基因变异既不能预测平均汉密尔顿抑郁量表评分，也不能预测缓解或反应时间。这些结果表明，FKBP 5不太可能在确定老年患者的抗抑郁治疗结果中发挥重要作用。
Genetic variation at the FKBP5 locus has been reported to affect clinical outcomes in patients treated with antidepressant medications in several studies. However, other reports have not confirmed this association. FKBP5 may regulate the sensitivity of the hypothalamic–pituitary–adrenal axis. We tested two FKBP5 single nucleotide polymorphisms (rs1360780 and rs3800373) in a sample of 246 geriatric patients treated for 8 weeks in a double-blind randomized comparison trial of paroxetine and mirtazapine. These two polymorphisms had previously been reported to predict efficacy in depressed patients treated with selective serotonin reuptake inhibitors such as paroxetine, and those treated with mirtazapine, an agent with both serotonergic and noradrenergic actions. However, we found no significant associations between these FKBP5 genetic variants and clinical outcomes. Neither mean Hamilton Depression Rating Scale scores nor time to remission or response were predicted by FKBP5 genetic variation. These results suggest that FKBP5 is unlikely to play a major role in determining antidepressant treatment outcomes in geriatric patients.
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影响因子：
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作者：
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DOI：
10.1097/00005072-199712000-00001
发表时间：
1997-12-01
影响因子：
3.2
作者：
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通讯作者：
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