Growth factors, extracellular matrix components and cell adhesion molecules Warthin's tumor.
Growth factors, extracellular matrix components and cell adhesion molecules Warthin's tumor.
复制标题
生长因子、细胞外基质成分和细胞粘附分子沃辛肿瘤。
DOI：
10.1034/j.1600-0714.2001.300506.x
复制
发表时间：
2001
影响因子：
3.3
通讯作者：
T. Nakashima
中科院分区：
文献类型：
--
作者：
Y. Nakamura;M. Yamamoto;K. Sakamoto;K. Ohta;A. Umeda;T. Tsukamoto;T. Nakashima
我们通过免疫组织化学和逆转录聚合酶链反应（RT-PCR）研究了唾液腺沃辛肿瘤中各种生长因子及其受体、细胞粘附分子和细胞外基质成分的表达。各种生长因子及其受体，如转化生长因子-α（TGF-α）、肝素结合表皮生长因子样生长因子（HB-EGF）、TGF-β2、TG-β3、胰岛素样生长因子（IGF）-I和-II、血管内皮生长因子（VEGF）、EGF受体（EGFR）、erb-B4、TGF-betaRI和II、Flt和Flk-1以及IGF受体Ibeta 存在于上皮细胞和/或某些淋巴细胞中。在淋巴组织的基质中发现纤连蛋白、层粘连蛋白、IV 型胶原蛋白和生腱蛋白。整合素如α3β1和β3、Thy-1、CD44和VCAM-1也在上皮细胞和/或淋巴细胞中表达。这些不同的蛋白质可能相互作用并调节这种独特肿瘤中上皮和淋巴成分的增殖和细胞附着。
We studied expressions of various growth factors, their receptors, cell adhesion molecules and extracellular matrix components in Warthin's tumor of the salivary gland with immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). Various growth factors and their receptors, such as transforming growth factor-alpha (TGF-alpha), heparin-binding epidermal growth factor-like growth factor (HB-EGF), TGF-beta2, TG-beta3, insulin-like growth factor (IGF)-I and -II, vascular endothelial growth factor (VEGF), EGF receptor (EGFR), erb-B4, TGF-betaRI and II, Flt and Flk-1 and IGF receptor Ibeta, were found in epithelial cells and/or in some lymphoid cells. Fibronectin, laminin, collagen type IV and tenascin were found in stroma of the lymphoid tissue. Integrins such as alpha3beta1 and beta3, Thy-1, CD44 and VCAM-1 were also expressed in epithelial and/or lymphoid cells. These various proteins may interact and regulate the proliferation and cell attachment of both epithelial and lymphoid components in this unique tumor.