Clinical significance of E-cadherin expression in thyroid neoplasms
Clinical significance of E-cadherin expression in thyroid neoplasms
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DOI：
10.1002/jso.1031
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发表时间：
2001-03-01
影响因子：
2.5
通讯作者：
Kobayashi, S
中科院分区：
文献类型：
--
作者：
Naito, A;Iwase, H;Kobayashi, S
Background and Objective: E-cadherin, a calcium-dependent transmembrane glycoprotein, is an adhesion molecule. We studied clinical significance of E-cadherin expression in thyroid neoplasms.Methods: We immunohistochemically studied E-cadherin expression in 60 normal tissue specimens of thyroid tissues and in 83 follicular adenomas, 53 papillary carcinomas, 4 follicular carcinomas, 2 medullary carcinomas, and 5 anaplastic carcinomas of the thyroid.Results: In papillary carcinoma, E-cadherin expression was preserved significantly less often than in follicular adenoma or normal thyroid tissue (P < 0.01). preserved E-cadherin expression was seen less often among papillary carcinomas with lymph node metastasis than in those without metastasis (P < 0.05).Conclusions: This loss of E-cadherin expression may be involved in regional lymph node metastasis and in malignant potential of thyroid neoplasms. (C) 2001 Wiley-Liss, Inc.
