Correlating the alpha rhythm to BOLD using simultaneous EEG/fMRI:: Inter-subject variability
Correlating the alpha rhythm to BOLD using simultaneous EEG/fMRI:: Inter-subject variability
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DOI：
10.1016/j.neuroimage.2005.09.062
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发表时间：
2006-03-01
期刊：
影响因子：
5.7
通讯作者：
da Silva, FHL
中科院分区：
文献类型：
--
作者：
Gonçalves, SI;de Munck, JC;da Silva, FHL
同时记录脑电图/功能磁共振图像（EEG/fMRI）用于识别与α节律自发变化相关的血氧水平依赖性（BOLD）变化，α节律被认为是大脑静息状态的标志。分析的重点是与静息状态相关的受试者间变异性。报告了7名正常受试者的数据。证实了先前的发现，3名受试者在枕叶、顶叶和额叶的广泛区域内，BOLD信号与α波段（8-12 Hz）内的平均功率时间序列呈负相关。在小的丘脑区域，BOLD信号与α功率呈正相关。被试3和被试4在数据采集时间内呈现两种不同的状态，显示出相应的相关模式不同，从而证明了结果的状态依赖性。在受试者5中，BOLD的变化主要发生在额叶和颞叶。受试者6只显示出正相关，从而与大多数受试者的负相关相矛盾。研究结果表明，不同受试者的静息状态是不同的，有时甚至在同一受试者中也是不同的。由于静息状态在许多功能磁共振实验中都扮演着重要的角色，因此在比较不同被试的功能磁共振结果时，需要解决静息状态在被试间的可变性。(c) 2005爱思唯尔公司版权所有。
Simultaneous recording of electroencephalogram/functional magnetic resonance images (EEG/fMRI) was applied to identify blood oxygenation level-dependent (BOLD) changes associated with spontaneous variations of the alpha rhythm, which is considered the hallmark of the brain resting state. The analysis was focused on inter-subject variability associated with the resting state. Data from 7 normal subjects are presented. Confirming earlier findings, three subjects showed a negative correlation between the BOLD signal and the average power time series within the alpha band (8-12 Hz) in extensive areas of the occipital, parietal and frontal lobes. In small thalamic areas, the BOLD signal was positively correlated with the alpha power. For subjects 3 and 4, who displayed two different states during the data acquisition time, it was shown that the corresponding correlation patterns were different, thus demonstrating the state dependency of the results. In subject 5, the changes in BOLD were observed mainly in the frontal and temporal lobes. Subject 6 only showed positive correlations, thus contradicting the negative BOLD alpha power cortical correlations that were found in most subjects. Results suggest that the resting state varies over subjects and, sometimes, even within one subject. As the resting, state plays an important role in many fMRI experiments, the inter-subject variability, of this state should be addressed when comparing fMRI results front different subjects. (c) 2005 Elsevier Inc. All rights reserved.