Reduced basal ganglia tissue-iron concentration in school-age children with attention-deficit/hyperactivity disorder is localized to limbic circuitry.
Reduced basal ganglia tissue-iron concentration in school-age children with attention-deficit/hyperactivity disorder is localized to limbic circuitry.
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DOI：
10.1007/s00221-022-06484-7
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发表时间：
2022-12
影响因子：
2
通讯作者：
中科院分区：
文献类型：
--
作者：
基底神经节中与多巴胺相关的异常与注意力缺陷/多动障碍（ADHD）有关。铁在支持多巴胺能功能中发挥着关键作用，脑铁和血清铁蛋白水平降低与儿童多动症症状的严重程度有关。此外，基底神经节是与多动症精神病理学有关的中央大脑区域，参与运动和奖励功能以及情绪反应。本研究重新利用弥散张量成像 (DTI) 来检查 ADHD 诊断和性别对 8-12 岁儿童基底神经节内铁沉积的影响。我们进一步探讨了脑铁水平与多动症症状严重程度和情感症状之间的关联。我们观察到，无论诊断如何，患有多动症的儿童双侧纹状体边缘区域的铁水平降低，以及男性感觉运动纹状体亚区域的铁沉积水平降低。在整个样本中，所有区域的铁沉积随着年龄的增长而增加。大脑行为分析显示，在诊断组中，双侧边缘纹状体中较低的组织铁水平与 ADHD 症状严重程度相关，而左侧边缘纹状体中较低的组织铁水平仅与焦虑、抑郁和情感症状严重程度相关。这项研究揭示了 ADHD 的神经生物学基础，特别强调了边缘区域组织铁缺乏的定位，并为重新利用 DTI 进行脑铁分析提供了支持。我们的研究结果强调需要进一步研究铁作为 ADHD 诊断和治疗以及性别差异的生物标志物。
Dopamine-related abnormalities in the basal ganglia have been implicated in attention-deficit/hyperactivity disorder (ADHD). Iron plays a critical role in supporting dopaminergic function, and reduced brain iron and serum ferritin levels have been linked to ADHD symptom severity in children. Furthermore, the basal ganglia is a central brain region implicated in ADHD psychopathology and involved in motor and reward functions as well as emotional responding. The present study repurposed diffusion tensor imaging (DTI) to examine effects of an ADHD diagnosis and sex on iron deposition within the basal ganglia in children ages 8–12 years. We further explored associations between brain iron levels and ADHD symptom severity and affective symptoms. We observed reduced iron levels in children with ADHD in the bilateral limbic region of the striatum, as well as reduced levels of iron-deposition in males in the sensorimotor striatal subregion, regardless of diagnosis. Across the whole sample, iron-deposition increased with age in all regions. Brain-behavior analyses revealed that, across diagnostic groups, lower tissue-iron levels in bilateral limbic striatum correlated with greater ADHD symptom severity, whereas lower tissue-iron levels in the left limbic striatum only correlated with anxious, depressive and affective symptom severity. This study sheds light on the neurobiological underpinnings of ADHD, specifically highlighting the localization of tissue-iron deficiency in limbic regions, and providing support for repurposing DTI for brain iron analyses. Our findings highlight the need for further investigation of iron as a biomarker in the diagnosis and treatment of ADHD and sex differences.
影响因子：
3.3
作者：
Kaso A;Ernst T
通讯作者：
Ernst T