IDENTIFICATION OF THORACIC INTERNEURONS THAT MEDIATE GIANT INTERNEURON-TO-MOTOR PATHWAYS IN THE COCKROACH
IDENTIFICATION OF THORACIC INTERNEURONS THAT MEDIATE GIANT INTERNEURON-TO-MOTOR PATHWAYS IN THE COCKROACH
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DOI：
10.1007/bf00612037
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发表时间：
1986-01-01
影响因子：
2.1
通讯作者：
POLLACK, AJ
中科院分区：
文献类型：
--
作者：
RITZMANN, RE;POLLACK, AJ
1.进行成对的细胞内记录以鉴定从巨中间神经元（GI）接收稳定的短潜伏期兴奋的胸中间神经元。2.其中8个后胸中间神经元的EPSP与胃肠道活动相关，胃肠道活动由风或细胞内电刺激诱发或自发发生。在所有情况下，胸中间神经元的EPSP在短时间内忠实地跟随GI动作电位。3.与GI动作电位相关的EPSP始终代表胸中间神经元中记录的大样本EPSP振幅的上限范围。4. 7个中间神经元与腹侧GI的活动相关，但与背侧GI的活动不相关。这些中间神经元中的四个是中间神经元的离散群体的一部分，其胞体位于神经节的背后部区域。第八中间神经元（指定的T细胞）与背侧GI的活动呈正相关。5.将四个背后组中间神经元和T细胞在细胞内去极化以建立它们产生运动活性的潜力。在所有情况下，位于中间神经元索马胞体对侧的腿部运动神经元（主要是Ds和共同抑制剂）的诱发活动更强。6.结果表明，存在显着的多突触通路GI活动可以引起运动活动。这一结论的影响，蟑螂逃逸系统的调查进行了讨论。
1. Paired intracellular recordings were made to identify thoracic interneurons that receive stable short latency excitation from giant interneurons (GIs). 2. Eight metathoracic interneurons were identified in which EPSPs were correlated with GI activity which was evoked either by wind or intracellular electrical stimulation or occurred spontaneously. In all cases EPSPs in the thoracic interneurons followed GI action potentials faithfully at short latencies. 3. EPSPs associated with GI action potentials consistently represented the upper range of amplitudes of a large sample of EPSPs recorded in the thoracic interneurons. 4. Seven of the interneurons were correlated with activity in ventral GIs but were not correlated with activity in dorsal GIs. Four of these interneurons were part of a discrete population of interneurons whose somata are located in the dorsal posterior region of the ganglion. The eighth interneuron (designated the T cell) was positively correlated with activity in dorsal GIs. 5. The four dorsal posterior group interneurons and the T cell were depolarized intracellularly to establish their potential for generating motor activity. In all cases evoked activity was stronger in leg motor neurons (primarily Ds and the common inhibitor) located on the side contralateral to the interneuron''s soma. 6. The results indicate that significant polysynaptic pathways exist by which GI activity can evoke motor activity. The implications of this conclusion to investigations on the cockroach escape system are discussed.