Seroprevalence of human herpes virus 8 in different Eritrean population groups
Seroprevalence of human herpes virus 8 in different Eritrean population groups
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DOI：
10.1016/s1386-6532(99)00061-x
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发表时间：
1999-12-01
影响因子：
8.8
通讯作者：
Linde, A
中科院分区：
文献类型：
--
作者：
Enbom, M;Tolfvenstam, T;Linde, A
背景：人类疱疹病毒8型（HHV-8）与卡波西肉瘤有关。在美国和欧洲，HHV-8被认为主要是性传播，但一些非洲国家的报告表明非性传播。目的：了解更多关于HHV-8在东非的血清阳性率和传播情况。研究设计：在这项研究中，411个血清样本，从不同的人群在厄立特里亚（儿童，孕妇，女性性工作者和孤立的Rashaida部落的成员）进行了检查HHV-8抗体与免疫荧光试验检测抗体潜伏和溶解HHV-8抗原。结果如下：在厄立特里亚儿童、孕妇、女性性工作者和Rashaidas中分别有0-2%、5%、8%和26%的人存在HHV-8潜伏抗原抗体。未发现可检测到的HHV-8抗体与HIV或单纯疱疹病毒血清阳性之间存在相关性。结论：这些结果表明，HHV-8感染在厄立特里亚相对普遍，病毒传播主要通过非性途径在该地区发生。(C)1999 Elsevier Science B. V.保留所有权利。
Background: Human herpesvirus 8 (HHV-8) is associated with Kaposi's sarcoma. In the US and Europe, HHV-8 is believed to be mainly sexually transmitted, but reports from some African countries suggest non-sexual transmission. Objectives: To find out more about HHV-8 seroprevalence and transmission in Eastern Africa. Study design: In this study, 411 serum samples from different population groups in Eritrea (children, pregnant women, female sex workers and members of the isolated Rashaida tribe) were examined for HHV-8 antibodies with an immunofluorescence assay detecting antibodies to latent and lytic HHV-8 antigens. Results: Antibodies to HHV-8 latent antigen were found in 0-2% of Eritrean children, 5% of pregnant women, 8% of female sex workers and 26% of Rashaidas, respectively. No correlation was found between detectable HHV-8 antibodies and seropositivity to HIV or herpes simplex. Conclusions: These results suggest that HHV-8 infection is relatively common in Eritrea and that viral transmission occurs predominantly through non-sexual route in this region. (C) 1999 Elsevier Science B.V. All rights reserved.