Brazilian multicenter study on prevalence of preterm birth and associated factors.
Brazilian multicenter study on prevalence of preterm birth and associated factors.
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DOI：
10.1186/1471-2393-10-22
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发表时间：
2010-05-19
影响因子：
3.1
通讯作者：
Brazilian Network of Studies on Reproductive and Perinatal Health
中科院分区：
文献类型：
--
作者：
Passini R Jr;Tedesco RP;Marba ST;Cecatti JG;Guinsburg R;Martinez FE;Nomura ML;Brazilian Network of Studies on Reproductive and Perinatal Health
早产的发生仍然是一个复杂的公共卫生状况。它被认为是新生儿发病和死亡的主要原因，导致存活儿童很可能留下后遗症。由于几个国家的发病率各不相同，在过去几十年中，这一现象明显增加。然而，在巴西，仍然难以估计其真实的发生率。因此，必须确定这种情况的流行程度和原因，以便提出预防行动。本研究旨在从全国各地的医院收集有关早产的患病率、相关的社会经济和环境因素、自发性早产、产前胎膜破裂和治疗性早产等原因导致的诊断和治疗方法以及新生儿结果的信息。该提案是一项多中心横断面研究加巢式病例对照研究，将在巴西几个地区的27个参考产科中心实施（北部：1;东北部：10;中西部：1;东南部：13;南部：2）。对于横断面部分，参与中心应在6个月内对所有住院分娩的患者进行前瞻性监测，以确定早产病例及其主要原因。在研究的前三个月，还将对与早产相关的因素进行分析，将早产妇女与足月分娩妇女进行比较。对于患病率研究，将对37，000例分娩（足月和早产）进行评价，相当于所有参与中心在12个月内分娩的大约一半。对于病例对照研究部分，估计样本量为每组（病例组和对照组）1，055名妇女。该研究的两个部分预计随访的早产儿总数约为3，600例。将通过问卷收集数据，所有患者将在分娩后回答。然后，这些数据将以电子形式编码，并通过互联网在线发送到中央数据库。将根据早产时的胎龄、可能原因、治疗管理和新生儿结局按亚组进行数据分析。然后，将估计可能的预测因子的相应比率、比率和相对风险。这些调查结果将提供有关巴西早产及其主要社会和生物风险因素的信息，支持卫生政策和实施关于早产预防和治疗战略的临床试验，这种情况对儿童及其家庭造成许多身体和情感后果。
The occurrence of preterm birth remains a complex public health condition. It is considered the main cause of neonatal morbidity and mortality, resulting in a high likelihood of sequelae in surviving children. With variable incidence in several countries, it has grown markedly in the last decades. In Brazil, however, there are still difficulties to estimate its real occurrence. Therefore, it is essential to establish the prevalence and causes of this condition in order to propose prevention actions. This study intend to collect information from hospitals nationwide on the prevalence of preterm births, their associated socioeconomic and environmental factors, diagnostic and treatment methods resulting from causes such as spontaneous preterm labor, prelabor rupture of membranes, and therapeutic preterm birth, as well as neonatal results. This proposal is a multicenter cross-sectional study plus a nested case-control study, to be implemented in 27 reference obstetric centers in several regions of Brazil (North: 1; Northeast: 10; Central-west: 1; Southeast: 13; South: 2). For the cross sectional component, the participating centers should perform, during a period of six months, a prospective surveillance of all patients hospitalized to give birth, in order to identify preterm birth cases and their main causes. In the first three months of the study, an analysis of the factors associated with preterm birth will also be carried out, comparing women who have preterm birth with those who deliver at term. For the prevalence study, 37,000 births will be evaluated (at term and preterm), corresponding to approximately half the deliveries of all participating centers in 12 months. For the case-control study component, the estimated sample size is 1,055 women in each group (cases and controls). The total number of preterm births estimated to be followed in both components of the study is around 3,600. Data will be collected through a questionnaire all patients will answer after delivery. The data will then be encoded in an electronic form and sent online by internet to a central database. The data analysis will be carried out by subgroups according to gestational age at preterm birth, its probable causes, therapeutic management, and neonatal outcomes. Then, the respective rates, ratios and relative risks will be estimated for the possible predictors. These findings will provide information on preterm births in Brazil and their main social and biological risk factors, supporting health policies and the implementation of clinical trials on preterm birth prevention and treatment strategies, a condition with many physical and emotional consequences to children and their families.
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影响因子：
158.5
作者：
Marlow, N;Wolke, D;Samara, M
通讯作者：
Samara, M
DOI：
10.1590/s1519-38292008000200009
发表时间：
2008-03-01
期刊：
Revista Brasileira de Saúde Materno Infantil
影响因子：
--
作者：
Reis, Liane G.;Silva, Cláudio Jerônimo da;Silva, Vilma Aparecida da
通讯作者：
Silva, Vilma Aparecida da
影响因子：
9.8
作者：
Ananth, Cande V.;Vintzileos, Anthony M.
通讯作者：
Vintzileos, Anthony M.
DOI：
10.1590/s0100-72032008000800004
发表时间：
2008-08-01
期刊：
Revista Brasileira de Ginecologia e Obstetrícia
影响因子：
--
作者：
Lajos, Giuliane Jesus;Passini Junior, Renato;Parpinelli, Mary Ângela
通讯作者：
Parpinelli, Mary Ângela
DOI：
10.1016/j.ogc.2005.03.001
发表时间：
2005-09-01
影响因子：
3.2
作者：
Klein, LL;Gibbs, RS
通讯作者：
Gibbs, RS