Two new dihydroisocoumarins with antimicrobial activities from the fungus Penicillium sp. XR046 collected from Xinren coal area
Two new dihydroisocoumarins with antimicrobial activities from the fungus Penicillium sp. XR046 collected from Xinren coal area
复制标题
两种新的二氢异香豆素，具有来自青霉属真菌的抗菌活性。
DOI：
10.1080/14786419.2019.1655019
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发表时间：
2019-08-23
影响因子：
2.2
通讯作者：
Liao, Shang-Gao
中科院分区：
文献类型：
--
作者：
Xu, Guo-Bo;Yang, Fei-Yu;Liao, Shang-Gao
从采自贵州省新仁矿区的青霉Penicillium sp. XR 046中分离得到两个新的二氢异香豆素类化合物（1和2）和六个已知化合物（3-8）。通过波谱分析鉴定了化合物的结构。通过与已知化合物的CD数据比较，确定了化合物1和2中C-3的绝对构型。化合物1-6显示出抗微生物活性，其对白色念珠菌、表皮葡萄球菌、枯草芽孢杆菌和大肠杆菌的MIC值在50至100 μ g/mL的范围内。
Two new dihydroisocoumarins (1 and 2), together with six known compounds (3-8), were isolated from the fungus Penicillium sp. XR046 collected from the Xinren coal area of Guizhou province in China. Their structures were elucidated on the basis of spectroscopic analysis. The absolute configurations of C-3 in 1 and 2 were established by comparison of their CD data with those of known compounds. Compounds 1-6 showed anti-microbial activities with MIC values in the range of 50 similar to 100 mu g/mL against Candida albicans, Staphylococcus epidermidis, Bacillus subtilis, and Escherichia coli.