Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: Its relation to liver lipid composition
Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: Its relation to liver lipid composition
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DOI：
10.1016/j.toxicon.2009.08.008
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发表时间：
2010-02-01
期刊：
影响因子：
2.8
通讯作者：
Marra, Carlos A.
中科院分区：
文献类型：
--
作者：
Sedan, Daniela;Andrinolo, Dario;Marra, Carlos A.
在小鼠中研究了 MC-LR 对肝脏和肾脏抗氧化系统的影响，以及长期暴露于亚致死剂量的微囊藻毒素 (MC) 后对肝脏脂质组成的影响。对小鼠进行腹腔注射治疗。每2天使用25μg MC-LR/kg体重或盐水溶液，持续一个月（发病阶段），然后在1个月和2个月的清除期间研究进展或恢复。在发病阶段，将 MC-LR 诱导的氧化损伤和治疗小鼠肝脏脂质的显着变化与对照小鼠进行比较。酶防御系统的明显依赖性表现为谷胱甘肽和 α-生育酚可用性的减少以及 NOx 产生的伴随增加。亚慢性 MC-LR 中毒导致脂质成分发生变化，包括减少 EFA/非 EFA、SFA/PUFA 和 n-3/n-6 比率均在恢复期间表现出缓慢恢复的模式。 (C) 2009 Elsevier Ltd. 保留所有权利。
The effects of MC-LR on antioxidant system in liver and kidney and its effects on hepatic lipid composition after prolonged exposure to sublethal doses of microcystins (MCs) were studied in mice. Mice were treated i.p. with 25 mu g of MC-LR/kg body weight or saline solution every 2 days for a month (inflictive stage), then progression or recovery was studied for 1 and 2 months of wash-out. During the inflictive stage, MC-LR-induced oxidative damage and significant changes in liver lipids of treated mice were compared with control mice.A clear dependence of the enzyme defense system was demonstrated with reduced glutathione and alpha-tocopherol availabilities and a concomitant elevation in NOx production.Sub-chronic MC-LR toxicosis produced alterations in lipid components that included a decreased EFA/non-EFA, SFA/PUFA, and n-3/n-6 ratios all of which exhibited a pattern of slow recovery during the recovery periods. (C) 2009 Elsevier Ltd. All rights reserved.