The absence of anti-Tat antibodies is associated with risk of disease progression in HIV-2 infection.
The absence of anti-Tat antibodies is associated with risk of disease progression in HIV-2 infection.
复制标题
抗 Tat 抗体的缺乏与 HIV-2 感染疾病进展的风险相关。
DOI：
10.1086/507042
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Kanki,PhyllisJ
中科院分区：
文献类型：
--
作者：
Rodriguez,ShaunK;Sarr,AbdoulayeDieng;Olorunnipa,Olushola;Popper,StephenJ;Gueye-Ndiaye,Aissatou;Traore,Ibrahima;Dia,MamadouC;Mboup,Souleymane;Kanki,PhyllisJ
人类免疫缺陷病毒（HIV）的达特蛋白是病毒复制所必需的，并且具有细胞外致病活性。我们试图确定是否抗Tat抗体反应是预测疾病进展的144例HIV-2感染者在1985年和2003年之间纵向观察。68%的受试者抗Tat抗体检测呈阳性，在血清转换后早期明显建立反应性，并在感染过程中稳定维持。抗Tat阴性受试者进展为晚期HIV-2 AIDS的风险和速率显著高于抗Tat阳性受试者，这扩展了该HIV-2 AIDS预后标志物的重要性
The Tat protein of human immunodeficiency virus (HIV) is essential for viral replication and has extracellular pathogenic activity. We sought to determine whether the anti-Tat antibody response was predictive of disease progression in 144 HIV type 2 (HIV-2)–infected subjects observed longitudinally between 1985 and 2003. Sixty-eight percent of the subjects tested positive for anti-Tat antibodies, with reactivity notably established early after seroconversion and stably maintained over the course of infection. The risk and rate of progression to advanced HIV-2 AIDS was significantly higher in anti-Tat–negative subjects than in anti-Tat–positive subjects, extending the importance of this prognostic marker for HIV-2 AIDS