Perceptually relevant remapping of human somatotopy in 24 hours
Perceptually relevant remapping of human somatotopy in 24 hours
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DOI：
10.7554/elife.17280
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发表时间：
2016-12-30
期刊：
影响因子：
7.7
通讯作者：
Johansen-Berg, Heidi
中科院分区：
文献类型：
--
作者：
Kolasinski, James;Makin, Tamar R.;Johansen-Berg, Heidi
大脑皮层功能图谱依赖于经验的重组在初级感觉皮层中得到了很好的描述。然而，短期内这种皮质重组的证据相对较少。使用人类体感皮层作为模型，我们研究了 24 小时粘合操作的效果，其中右手食指和右手中指（数字 2 和数字 3）用手术胶水连接。使用两个 7 特斯拉 fMRI 协议评估的体位表征显示，粘合后非操作手指发生快速脱靶重组，无名指（数字 4）的表征向小指（数字 5）移动，远离中指（数字 3）。这些转变在独立队列中进行的两项行为任务中也很明显，显示出区分无名指和小指刺激时间顺序的敏感性降低，并且在快速反应时间任务中这对人的替代错误增加。
Experience-dependent reorganisation of functional maps in the cerebral cortex is well described in the primary sensory cortices. However, there is relatively little evidence for such cortical reorganisation over the short-term. Using human somatosensory cortex as a model, we investigated the effects of a 24 hr gluing manipulation in which the right index and right middle fingers (digits 2 and 3) were adjoined with surgical glue. Somatotopic representations, assessed with two 7 tesla fMRI protocols, revealed rapid off-target reorganisation in the non-manipulated fingers following gluing, with the representation of the ring finger (digit 4) shifted towards the little finger (digit 5) and away from the middle finger (digit 3). These shifts were also evident in two behavioural tasks conducted in an independent cohort, showing reduced sensitivity for discriminating the temporal order of stimuli to the ring and little fingers, and increased substitution errors across this pair on a speeded reaction time task.