Thermal inkjet printing in tissue engineering and regenerative medicine.
Thermal inkjet printing in tissue engineering and regenerative medicine.
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DOI：
10.2174/187221112800672949
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发表时间：
2012-08
影响因子：
--
通讯作者：
Lotz MK
中科院分区：
文献类型：
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作者：
Cui X;Boland T;D'Lima DD;Lotz MK
生物打印具有高通量、数字控制以及将细胞和生物材料支架高度精确地放置到所需的2D和3D位置的优点，在转化医学和器官替代领域具有巨大的潜力。本文综述了基于热喷墨打印技术的器官和组织生物打印的最新进展。生物打印对打印的哺乳动物细胞没有或几乎没有副作用，并且可以在组织构建的精确放置过程中方便地联合收割机与基因转染或药物递送结合到弹出的生命系统中。通过逐层组装，可以使用扫描的CT或MRI图像打印具有复杂结构的3D组织。血管或神经系统可以在数字控制的器官构建过程中同时启用。因此，生物打印是解决具有血管系统的厚且复杂组织制造中这一关键问题的唯一解决方案。总之，基于热喷墨的生物打印在组织工程和再生医学领域具有巨大的潜力和广阔的应用前景。本文介绍了生物打印技术在组织工程领域中的应用，以及生物打印技术在生命系统中的应用。
With the advantages of high throughput, digital control, and highly accurate placement of cells and biomaterial scaffold to the desired 2D and 3D locations, bioprinting has great potential to develop promising approaches in translational medicine and organ replacement. The most recent advances in organ and tissue bioprinting based on the thermal inkjet printing technology are described in this review. Bioprinting has no or little side effect to the printed mammalian cells and it can conveniently combine with gene transfection or drug delivery to the ejected living systems during the precise placement for tissue construction. With layer-by-layer assembly, 3D tissues with complex structures can be printed using scanned CT or MRI images. Vascular or nerve systems can be enabled simultaneously during the organ construction with digital control. Therefore, bioprinting is the only solution to solve this critical issue in thick and complex tissues fabrication with vascular system. Collectively, bioprinting based on thermal inkjet has great potential and broad applications in tissue engineering and regenerative medicine. This review article introduces some important patents related to bioprinting living systems and the bioprinting in tissue engineering field.