SHV-28, an extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae in south India.
SHV-28, an extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae in south India.
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DOI：
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发表时间：
2009
影响因子：
1.6
通讯作者：
S. Jemima;S. Verghese
中科院分区：
文献类型：
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作者：
S. Jemima;S. Verghese
SHV-28是一种来自肺炎克雷伯菌临床分离株的超广谱β-内酰胺酶，其等电点为7.6，底物谱显示头孢噻肟优先水解头孢他啶。它与SHV-1的区别在于一个氨基酸取代。通过SHV-28蛋白质序列分析，确定了其保守的S-T-F-K和K-T-G基序。
SHV-28, an extended spectrum beta-lactamase from a clinical isolate of Klebsiella pneumoniae , had an isoelectric point of 7.6 and a substrate profile showing preferential hydrolysis for cefotaxime over ceftazidime. It differed from SHV-1 by one amino acid substitution. The conserved S-T-F-K and K-T-G motifs were identified by SHV-28 protein sequencing.