Relative entropy differences in bacterial chromosomes, plasmids, phages and genomic islands.
Relative entropy differences in bacterial chromosomes, plasmids, phages and genomic islands.
复制标题
DOI：
10.1186/1471-2164-13-66
复制
发表时间：
2012-02-10
期刊：
影响因子：
4.4
通讯作者：
Hardy SP
中科院分区：
文献类型：
--
作者：
Bohlin J;van Passel MW;Snipen L;Kristoffersen AB;Ussery D;Hardy SP
我们试图评估相对熵（信息容量）的概念是否有助于我们理解微生物中水平基因转移的过程。我们分析了原核染色体、基因组岛（GI）、质粒和质粒之间信息容量的差异。使用Kullback-Leibler测度估计相对熵。相对熵在细菌染色体中最高，其大小顺序为染色体> GI >噬菌体>质粒.相对熵与染色体、叶绿体、质粒和GI中的AT含量存在相关性，其中以叶绿体中的AT含量相关性最强。相对熵也被发现是在专性胞内麻风分枝杆菌低于相关的M。结核病的一个共同的高度保守的基因集测量。我们认为，相对熵的差异反映了质粒，质粒和地理信息系统与微生物宿主染色体的相互作用，所有这些生物实体，或已经受到不同的选择压力。染色体内水平获得的DNA的改善率可能是染色体和稳定掺入的GI之间的小差异与瞬时或独立复制子（如DNA和质粒）相比的原因。
We sought to assess whether the concept of relative entropy (information capacity), could aid our understanding of the process of horizontal gene transfer in microbes. We analyzed the differences in information capacity between prokaryotic chromosomes, genomic islands (GI), phages, and plasmids. Relative entropy was estimated using the Kullback-Leibler measure. Relative entropy was highest in bacterial chromosomes and had the sequence chromosomes > GI > phage > plasmid. There was an association between relative entropy and AT content in chromosomes, phages, plasmids and GIs with the strongest association being in phages. Relative entropy was also found to be lower in the obligate intracellular Mycobacterium leprae than in the related M. tuberculosis when measured on a shared set of highly conserved genes. We argue that relative entropy differences reflect how plasmids, phages and GIs interact with microbial host chromosomes and that all these biological entities are, or have been, subjected to different selective pressures. The rate at which amelioration of horizontally acquired DNA occurs within the chromosome is likely to account for the small differences between chromosomes and stably incorporated GIs compared to the transient or independent replicons such as phages and plasmids.
登录
查看更多内容
影响因子：
3
作者：
Langille MG;Hsiao WW;Brinkman FS
通讯作者：
Brinkman FS
影响因子：
3.9
作者：
Lawrence, JG;Ochman, H
通讯作者：
Ochman, H
影响因子：
4.4
作者：
Bohlin, Jon;Skjerve, Eystein;Ussery, David W.
通讯作者：
Ussery, David W.
影响因子：
4.4
作者：
Roos TE;van Passel MW
通讯作者：
van Passel MW
使用orthomcl将蛋白质分配给Orthomcl-DB组或将蛋白质组群集分为新的直系同源组。
影响因子：
--
作者：
Fischer, Steve;Brunk, Brian P;Chen, Feng;Gao, Xin;Harb, Omar S;Iodice, John B;Shanmugam, Dhanasekaran;Roos, David S;Stoeckert, Christian J Jr
通讯作者：
Stoeckert, Christian J Jr