Polycyclic Hybrid Isoprenoids from a Reed Rhizosphere Soil Derived Streptomyces sp CHQ-64
Polycyclic Hybrid Isoprenoids from a Reed Rhizosphere Soil Derived Streptomyces sp CHQ-64
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来自芦苇根际土壤的链霉菌 CHQ-64 的多环杂种异戊二烯
DOI：
10.1021/np3008864
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发表时间：
2013-04-01
影响因子：
5.1
通讯作者：
Li, Dehai
中科院分区：
文献类型：
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作者：
Che, Qian;Zhu, Tianjiao;Li, Dehai
从芦苇根际土壤放线菌链霉菌CHQ-64中分离得到两个新的杂合类异戊二烯化合物，分别命名为indotertine B（2）和drimentine H（3），沿着已知的类似物drimentine C（4）。通过广泛的NMR、MS和CD分析阐明了这些化合物的结构，包括绝对构型。Indotertine B（2）在N-C（O）键附近以2：1的比例存在一对旋转异构体，对HCT-8和A549肿瘤细胞系显示活性，IC 50值分别为6.96和4.88 μ M。
Two new hybrid isoprenoids, named indotertine B (2) and drimentine H (3), along with the known analogue drimentine C (4), were isolated from the reed rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64. The structures of these compounds, including absolute configurations, were elucidated by extensive NMR, MS, and CD analyses. Indotertine B (2) exists as a pair of rotamers about the N-C(O) bond with a 2:1 ratio and displays activities against HCT-8 and A549 tumor cell lines with IC50 values of 6.96 and 4.88 mu M, respectively.