National survey of pellucid marginal corneal degeneration in Japan.
National survey of pellucid marginal corneal degeneration in Japan.
复制标题
日本透明边缘角膜变性全国调查。
DOI：
10.1007/s10384-016-0462-0
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发表时间：
2016
期刊：
影响因子：
2.4
通讯作者：
Kazuo Tsubota; Japan Pellucid Marginal Corneal Degeneration Study Group
中科院分区：
文献类型：
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作者：
Jun Shimazaki;Naoyuki Maeda;Osamu Hieda;Yuichi Ohashi;Akira Murakami;Kohji Nishida;Kazuo Tsubota; Japan Pellucid Marginal Corneal Degeneration Study Group
PurposeA全国性调查在日本进行，以分析透明边缘角膜变性（PMD）的临床特征。方法向日本角膜协会的所有成员发送问卷，要求对PMD患者的人口统计学和临床结果进行检查，2008年至2010年。带状周边角膜变薄，裂隙灯生物显微镜或测厚图检测的存在下，被设置为PMD的诊断标准。ResultsMost的参与设施依赖于裂隙灯生物显微镜或角膜地形图作为诊断工具，用于PMD的检测。从参与机构返回347例患者（579只眼）的数据进行分析，其中84例男性和24例女性的162只眼符合PMD标准，中位发病年龄为37岁。 108例（162眼）经典型PMD患者中，单侧受累者占25%（27眼）。在27只对侧眼有局部解剖发现的眼中，有17只眼睛有7只眼睛是圆锥角膜或疑似圆锥角膜诊断。在24只眼（22.2%的患者）中发现与过敏性疾病相关。大约一半的患者的矫正远视力为1.0或更好，只有5%的患者的矫正远视力为0.1或更差。平均角膜曲率值为45.7屈光度。在角膜地形图，100只眼睛（61.7%）显示的地形“蟹爪图案”，其余的眼睛显示其他模式，包括下陡峭（22.2%）和不规则的图案（10.5%）。ConclusionsWe进行了最大的PMD的临床调查，到目前为止，发现男性占主导地位，相对较高的患病率的单方面参与，和相关的过敏性疾病。
PurposeA national survey was conducted in Japan to analyze the clinical characteristics of pellucid marginal corneal degeneration (PMD).MethodsA questionnaire was sent to all members of the Japan Cornea Society requesting demographic and clinical findings on PMD patients who had been examined between 2008 and 2010. The presence of band-shaped peripheral corneal thinning, detected by slit-lamp biomicroscopy or by a pachymetric map, was set as the diagnostic criterion of PMD.ResultsMost of the participating facilities relied on either slit-lamp biomicroscopy or corneal topography as diagnostic tools for the detection of PMD. Data on 347 patients (579 eyes) were returned from the participating facilities for analysis, among which 162 eyes in 84 men and 24 women, with a median onset age of 37 years, met the PMD criteria. Of the 108 patients (162 eyes) with classical PMD, unilateral involvement was found in 25 % of patients (27 eyes). In 17 of the 27 eyes for which topographic findings for the contralateral eye were available, seven eyes were either keratoconus or had a suspected diagnosis of keratoconus. An association with allergic disease was found in 24 eyes (22.2 % of patients). Approximately half of the patients had 1.0 or better spectacle-corrected distance visual acuity, and only 5 % showed 0.1 or worse. The mean keratometric value was 45.7 diopters. On corneal topography, 100 eyes (61.7 %) showed the topographic “crab-claw pattern,” and the remaining eyes showed other patterns, including inferior steepening (22.2 %) and an irregular pattern (10.5 %).ConclusionsWe conducted the largest clinical survey of PMD to date and found a male predominance, a relatively high prevalence of unilateral involvement, and associated allergic diseases.