Relationship of uric acid with progression of kidney disease
Relationship of uric acid with progression of kidney disease
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DOI：
10.1053/j.ajkd.2007.05.013
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发表时间：
2007-08-01
影响因子：
13.2
通讯作者：
Fried, Linda F.
中科院分区：
文献类型：
--
作者：
Chonchol, Michel;Shlipak, Michael G.;Fried, Linda F.
背景：肾功能不全患者的尿酸水平升高。我们测试了尿酸可能与肾脏疾病进展相关的假设。研究设计：队列研究。设置和参与者：心血管健康研究的 5,808 名参与者。预测因素：尿酸水平。结果和测量：肾脏疾病进展定义为估计肾小球滤过率 (GFR) 每年下降 3 mL/min/1.73 m(2) 或更高 (>= 0.05 mL/s)，并作为事件慢性肾脏病（CKD）。肾功能的测量是使用肾病饮食修改研究方程估计 GFR。结果：尿酸水平较高的五分位数与估计 GFR 低于 60 mL/min/1.73 m(2) 的患病率较高相关（
Background: Uric acid levels are increased in patients with kidney dysfunction. We tested the hypothesis that uric acid may be associated with kidney disease progression.Study Design: Cohort study.Setting & Participants: 5,808 participants of the Cardiovascular Health Study.Predictor: Uric acid levels.Outcomes & Measurements: Kidney disease progression was defined as a decrease in estimated glomerular filtration rate (GFR) of 3 mL/min/1.73 m(2) per year or greater (>= 0.05 mL/s) and as incident chronic kidney disease (CKD). Measures of kidney function were estimated GFR using the Modification of Diet in Renal Disease Study equation.Results: Higher quintiles of uric acid levels were associated with greater prevalences of estimated GFR less than 60 mL/min/1.73 m(2) (