FOX(M1) news--it is cancer.
FOX(M1) news--it is cancer.
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DOI：
10.1158/1535-7163.mct-12-0712
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发表时间：
2013-03
影响因子：
5.7
通讯作者：
Gartel AL
中科院分区：
文献类型：
--
作者：
Halasi M;Gartel AL
FOXM1是Forkhead家族的致癌转录因子，在细胞增殖和细胞周期进程中具有明确的作用。FOXM1的表达在静止或分化的细胞中被排除，但其水平在增殖和恶性细胞中高度升高。据报道，FOXM1在20多种人类癌症中过表达。近年来，FOXM1参与了多种细胞过程，越来越多的实验数据强调了FOXM1与肿瘤发生的相关性。尽管FOXM1受三种主要肿瘤抑制因子（RB，p53，p19ARF）的控制，但它在大多数人类癌症中仍然具有活性。FOXM1的致癌潜力主要基于其转录激活参与癌症发展不同方面的基因的能力。在这篇综述中，FOXM1对癌症的每一个标志的贡献将被总结和讨论。
FOXM1 is an oncogenic transcription factor of the Forkhead family and it has a well-defined role in cell proliferation and cell cycle progression. Expression of FOXM1 is excluded in quiescent or differentiated cells, but its level is highly elevated in proliferating and malignant cells. Overexpression of FOXM1 has been reported in more than 20 types of human cancer. In recent years, FOXM1 has been implicated in diverse cellular processes and also a growing body of experimental data has underlined the relevance of FOXM1 in tumorigenesis. Although FOXM1 is under the control of three major tumor suppressors (RB, p53, p19ARF), it is still active in the majority of human cancers. The oncogenic potential of FOXM1 is mainly based on its ability to transcriptionally activate genes that are involved in different facets of cancer development. In this review, the contribution of FOXM1 to each of the hallmarks of cancer will be summarized and discussed.