Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway
复制标题
半抗原特异性 T 细胞对 4-羟基-3-硝基苯基乙酰基的反应。
DOI：
--
复制
发表时间：
1980
影响因子：
15.3
通讯作者：
M. Dorf
中科院分区：
文献类型：
--
作者：
J. Weinberger;R. Germain;B. Benacerraf;M. Dorf
4-Hydroxy-3-nitrophenyl (NP) derivatized syngeneic spleen cells injected intravenously stimulate maturation of an antigen-binding, idiotype-bearing induction-phase suppressor cell population, as well as an idiotype-binding anti-idiotype-bearing effector-phase suppressor cell population. Both cell types are present simultaneously in the spleen cell population 7-d after their induction. Furthermore, the cell population with antigen-binding properties can, in the presence of NP- derivatized syngeneic cells, induce a population of effector suppressor cells. The precursors of the effector suppressor population are not sensitive to concentrations of cyclophosphamide which prevented the generation of induction phase suppressor cells. These data provide direct evidence in support of the theory of network regulation of immune suppression. X
用抗原修饰的同系细胞进行体内免疫抑制。
DOI：
--
发表时间：
1980
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Sherr,DH;Benacerraf,B;Dorf,ME
通讯作者：
Dorf,ME